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ISAD

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Individual Synaptic Activity Detection (ISAD)

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ISAD is a peak detection software that detects individual (pre-)synaptic activity in microscopy images from neuronal cultures transfected with pHluorin. It computes synaptic signals from automatically segmented regions of interest and detects peaks that represent vesicle fusion events, thus, pre-synaptic activity. ISAD is based on MWA, which is a continuous wavelet transform based algorithm that employs multiple wavelets and is published as:
Sokoll, S., Tönnies, K., and Heine, M. Detection of Spontaneous Vesicle Release at Individual Synapses Using Multiple Wavelets in a CWT-Based Algorithm. Med Image Comput Comput Assist Interv (MICCAI). 2012;15(Pt 1):165-72

ISAD is written in MATLAB and comes with a graphical user interface.

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    Great stuff.

    Posted 06/18/2013
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Additional Project Details

Intended Audience

Science/Research

Programming Language

MATLAB

Registered

2012-05-25

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