EpidermalERKMAPK

A collection of scripts which examine the activation/phosphorylation of ERK-MAPK signalling components across the depth of human epidermis. This code accompanies the publication: Cursons, J. et al (2015). Regulation of ERK-MAPK Signalling in Human Epidermis. BMC Systems Biology. doi: 10.1186/s12918-015-0187-6

The model was developed using a set the normalized-Hill differential equation framework, as specified by [Kraeutler, Soltis & Saucerman, (2002). BMC Systems Biology; doi: 10.1186/1752-0509-4-157].

This package includes:
- MATLAB code containing the model definition, together with a script to perform non-linear least squares optimisation for a subset of parameters
- python scripts which use libSBML to create an SBML representation of the model
- SED-ML scripts which execute the SBML model under a range of conditions, produce output plots to recapitulate results shown in Cursons et al. (2015).

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SEDML time course output for executing EpidermalERKMAPK.xml at varying spatial positions

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