An ultrafast and versatile algorithm that searches for potential off-target sites of CRISPR/Cas-derived RNA-guided endonucleases.

Cas-OFFinder is an ultrafast and highly versatile off-target searching tool. Importantly, Cas-OFFinder is written in OpenCL, enabling operation in diverse platforms such as central processing units (CPUs), graphics pro-cessing units (GPUs), digital signal processors (DSPs), and other processors.

Cas-OFFinder runs on Windows and POSIX (portable operating system interface) platforms.

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2013-11-11