vbSPT is an acronym for variational Bayes single particle tracking, a software package for  hidden Markov Model analysis of single particle tracking data, primarily for biophysical applications.
Journal reference: 
Extracting intracellular diffusive states and transition rates from single-molecule tracking data. Fredrik Persson, Martin Lindén, Cecilia Unoson & Johan Elf. Nature Methods (2013).
doi:10.1038/nmeth.2367
http://www.nature.com/nmeth/journal/vaop/ncurrent/abs/nmeth.2367.html
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