Custom ISO's of Mario Kart Wii (Vintage Kart Wii v1.6 and New Mario Kart 7) for some odd reason don't work with the DOL patched to include Ocarina codes that allow custom lapcounts, coursespeed and more. ISO runs fine on Dolphin and even CFG USB Loader, using cIOS 249 (d2x v10beta53-alt base56).
Tried all kinds of options, including blocking of IOS Reload (which seems what CFG did when booting), which suggests that there is something strange induced by USB Loader GX that causes the custom code in the DOL not to function. I have manually extracted the ISO and found only one boot.dol, so it can't be alternate DOLs or something.
I understand the notice above states to not file issues for games, but since this very peculiar bug happens on USB Loader GX, but not Dolphin or another USB Loader, I would find it appropriate to look into it.