Re: [Toxtree-users] Double negatives in ToxTree pdf file output

[Nina J. <jel...@gm...>]

Dear Ewan,

The messages are indeed confusing. The QSARs are only applicable to
specific classes (aromatic amines and alpha,beta unsaturated aldehydes),
hence the QSAR related entries for ethanol should be ignored.

Unlikely to be a S. typhimurium TA100 mutagen based on QSAR =YES is not the
proper answer, as it assumes the QSAR was launched and the outcome was YES.
This is not the case. I'll be checking with ISS (the rules authors) how to
improve these messages.

Best regards,
Nina


On 23 August 2013 17:37, <ewa...@sy...> wrote:

>  I am being confused by the output files saved as pdf from running for
> example the Carcinogenicity and mutagenicity rule base by ISS.  If you open
> the enclosed report you will see the highlighted statements for a trivial
> example run on ethanol to highlight my concerns.****
>
> ** **
>
> QSAR = NO****
>
> Unlikely to be a S. typhimurium TA100 mutagen based on QSAR = NO  (therefore
> the statement means yes likely to be a TA100 mutagen since the statement is
> a double negative)****
>
> Potential carcinogen based on QSAR = NO****
>
> Unlikely to be a carcinogen based on QSAR = NO  (here again the response
> actually means yes the material is likely to be a carcinogen)****
>
> ** **
>
> Hence I am concerned about submitting reports from ToxTree as a reviewer
> will read these statement as saying the assessment concludes the material
> *is *mutagenic and carcinogenic.  I noted a similar issue with 2.5.0 but
> did not get round to asking about it, just installed 2.6.0.****
>
> ** **
>
> Is this the intention?  I would expect either the statement should be:-***
> *
>
> ** **
>
> QSAR = NO****
>
> Unlikely to be a S. typhimurium TA100 mutagen based on QSAR = YES  (hence
> not mutagenic)****
>
> Potential carcinogen based on QSAR = NO****
>
> Unlikely to be a carcinogen based on QSAR = YES  (hence not a carcinogen)*
> ***
>
> ** **
>
> Thanks for your help****
>
> ** **
>
> Regards ****
>
> Ewan ****
>
> Dr Ewan D Booth,
> Product Safety Dept, Syngenta Ltd,  Jealott's Hill International Research
> Centre, Bracknell, Berkshire RG42 6EY, UK
> email: ewa...@sy...
> tel: +44 (0)1625 827386
> mob: +44 (0)7590 354251
>
>
> ****
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