When trying to build Lincoln Stein's Bio::SCF Perl module, which depends on the Staden libread, problems of endiannes detection happen on some architectures. You can see the in the build logs at the following page: https://buildd.debian.org/pkg.cgi?pkg=libbio-scf-perl
The following patch was sent in the Debian Bug tracking system and should solve the problem. Do you think you can release a new upstream version that includes it ?
Have a nice week-end,