#4 Mean CRH concentrations too low

[Johannes W. Dietrich]

Mean portal CRH concentrations are too low. According to newer research, a reasonable value would be be around 5 pmol/L.

References

1. Smith RF, French NP, Saphier PW, Lowry PJ, Veldhuis JD, Dobson H. Identification of stimulatory and inhibitory inputs to the hypothalamic-pituitary-adrenal axis during hypoglycaemia or transport in ewes. J Neuroendocrinol. 2003 Jun;15(6):572-85. doi: 10.1046/j.1365-2826.2003.01038.x. PMID: 12716408.
2. Sapolsky RM, Armanini MP, Sutton SW, Plotsky PM. Elevation of hypophysial portal concentrations of adrenocorticotropin secretagogues after fornix transection. Endocrinology. 1989 Dec;125(6):2881-7. doi: 10.1210/endo-125-6-2881. PMID: 2555130.
3. Conte-Devolx B, Guillaume V, Boudouresque F, Graziani N, Magnan E, Grino M, Emperaire N, Nahoul K, Cataldi M, Oliver C. Effects of metyrapone infusion on corticotropin-releasing factor and arginine vasopressin secretion into the hypophysial portal blood of conscious, unrestrained rams. Acta Endocrinol (Copenh). 1992 Nov;127(5):435-40. doi: 10.1530/acta.0.1270435. PMID: 1471455.
4. Caraty A, Grino M, Locatelli A, Oliver C. Secretion of corticotropin releasing factor (CRF) and vasopressin (AVP) into the hypophysial portal blood of conscious, unrestrained rams. Biochem Biophys Res Commun. 1988 Sep 15;155(2):841-9. doi: 10.1016/s0006-291x(88)80572-2. PMID: 3048263.

[Johannes W. Dietrich]

Adressed in SimulAdren 2.1.