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A simulation program for thyroid homeostasis.
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From: Johannes W. D. <joh...@ru...> - 2022-04-23 21:10:19
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SimThyr has been updated to version 4.0.6. This release fixes a bug, where certain loads (TRH tests and TBG rise in pregnancy or on oral anticonception) weren't correctly handled. The new version is available for macOS, Windows, Linux and other major operating systems. As always, it can be downloaded from https://simthyr.sourceforge.io <https://simthyr.sourceforge.io/>, https://sourceforge.net/projects/simthyr/ <https://sourceforge.net/projects/simthyr/> or https://doi.org/10.5281/zenodo.1303822 <https://doi.org/10.5281/zenodo.1303822>. Release notes can be read at https://sourceforge.net/p/simthyr/wiki/Version_History/. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — Call for papers: We have launched a Research Topic on Thyroid Hormones and Cardiac Arrhythmia in the journals Frontiers in Endocrinology and Frontiers in Cardiovascular Medicine. To participate please visit https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. |
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From: Johannes W. D. <joh...@ru...> - 2022-04-23 21:05:28
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With immediate effect, a special version of SimThyr is also available for command-line interfaces. This edition is intended for science and research use. It supports remote control and automation on the local computer and on distant hosts. SimThyr CLI has for a long time been used for internal purposes, but after maturation it has now been made available for the public. It can be downloaded from https://simthyr.sourceforge.io, https://sourceforge.net/projects/simthyr/ or https://doi.org/10.5281/zenodo.1303822. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — Call for papers: We have launched a Research Topic on Thyroid Hormones and Cardiac Arrhythmia in the journals Frontiers in Endocrinology and Frontiers in Cardiovascular Medicine. To participate please visit https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. |
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From: Johannes W. D. <joh...@ru...> - 2022-01-07 17:51:59
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SimThyr 4.0.5 is available for all major platforms. This version is a recommended bug-fix release. The new release can be downloaded from https://sourceforge.net/projects/simthyr/, https://simthyr.sourceforge.io or https://doi.org/10.5281/zenodo.1303822 <https://doi.org/10.5281/zenodo.1303822>. See https://sourceforge.net/p/simthyr/wiki/Version_History/ for release notes. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — Call for papers: We have launched a Research Topic on Thyroid Hormones and Cardiac Arrhythmia in the journals Frontiers in Endocrinology and Frontiers in Cardiovascular Medicine. To participate please visit https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. |
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From: Johannes W. D. <joh...@ru...> - 2021-12-31 21:35:42
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SimThyr has been updated to version 4.0.4 (macOS only). This release fixes a few minor bugs. As always SimThyr is available from http://simthyr.sf.net and from https://doi.org/10.5281/zenodo.1303822. Best wishes and happy new year, JWD -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- — Call for papers: We have launched a Research Topic on Thyroid Hormones and Cardiac Arrhythmia in the journals Frontiers in Endocrinology and Frontiers in Cardiovascular Medicine. To participate please visit https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. |
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From: Johannes W. D. <joh...@ru...> - 2020-09-01 21:27:08
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SimThyr 4.0.3, a bug fix release, has been released. Thanks to Henrik Glensbo from Denmark some stability issues could be addressed. Additionally, this is the first version to be notarised by Apple, thereby facilitating easy installation on newer versions of macOS. Of course, SimThyr continues to be available for Windows and Linux, too. Version 4.0.3 is available from http://simthyr.sf.net or https://doi.org/10.5281/zenodo.1303822. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2020-03-31 21:35:08
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With immediate effect, SimThyr 4.0.2 is available. Although it doesn't come with new features, it implements, however, multiple bug fixes (thanks especially to Henrik Glensbo for reporting several issues). Additionally, it is the first version to support the Cocoa API, 64-bit processors and the dark mode on macOS. This is a recommended update. The new version may be downloaded e.g. from http://simthyr.sf.net or (with a delay of one day) from https://doi.org/10.5281/zenodo.1303822. JWD -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2019-06-01 22:14:35
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With immediate effect, SimThyr is available in version 4.0.1. This is a bug-fix release that is recommended for all users. Fixed bugs include missing units of measurement in comboboxes in the preferences dialog box, a problem with the code signature for macOS and an occasionally arising (and nearly intractable) bug that prevented drawing of nullcline plots in certain situations. SimThyr 4.0.1 is available for macOS, Windows and Linux. Please see http://simthyr.sf.net or http://simthyr.sourceforge.io for more information. JWD -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2018-07-16 21:10:38
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With immediate effect, SimThyr is available in the Zenodo repository. Zenodo is a European research OpenScience initiative created by OpenAIRE and CERN. Its aim is to support open access to research data, software and tools. See https://www.zenodo.org/record/1305051 for details. Zenodo also provides digitial object identifiers (DOIs) for every version of SimThyr. A universal DOI for all versions is 10.5281/zenodo.1303822. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "joh...@ru..." -- http://www.thyreologie.com.de -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2017-04-20 19:05:53
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The handbook for SimThyr has been updated to reflect version 4.0. It is available from http://simthyr.sourceforge.net/manual.html along with archived previous versions. J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. med. Johannes W. Dietrich -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: tel:+49-234-302-6400, Fax: tel:+49-234-302-6403 -- eMail: "j.w...@me..." -- http://www.thyreologie.com.de -- GND 123571073 | VIAF 69838628 | Researcher ID C-3498-2009 -- ISNI: 0000 0000 1275 0811 | ORCID ID: 0000-0002-1185-3549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2017-04-13 18:59:50
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We are pleased to announce SimThyr 4.0, a major re-write of the popular virtual thyroid homeostasis software. This version features a plethora of new functions, including but not limited to null isocline plots, enhanced data export options and model annotations supporting the creation of MIRIAM-compliant models. This functionality required two years of development and a partial re-implementation of the simulation engine and more than 130 SVN commits. In additions, multiple bugs have been fixed. SimThyr 4.0 is compatible to macOS, Windows and Linux. The free software is available from http://simthyr.sf.net . J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. med. Johannes W. Dietrich -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: tel:+49-234-302-6400, Fax: tel:+49-234-302-6403 -- eMail: "j.w...@me..." -- http://www.thyreologie.com.de -- GND 123571073 | VIAF 69838628 | Researcher ID C-3498-2009 -- ISNI: 0000 0000 1275 0811 | ORCID ID: 0000-0002-1185-3549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2016-04-11 18:54:48
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Good news, SimThyr has been curated by SciCrunch. SciCrunch, a "cooperative and collaborative data and resource discovery platform for scientific communities", is a key tool of the Resource Identification Initiative. From now on, authors can easily cite SimThyr by adding its RRID to their papers. See http://scicrunch.org/browse/resources/SCR_014351 and https://www.force11.org/group/resource-identification-initiative for more details. From now on, you may cite SimThyr properly as (SimThyr, RRID:SCR_014351). J. W. Dietrich -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. med. Johannes W. Dietrich -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- http://www.thyreologie.com.de -- GND 123571073 | VIAF 69838628 | Researcher ID C-3498-2009 -- ISNI: 0000 0000 1275 0811 | ORCID ID: 0000-0002-1185-3549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2015-04-13 21:52:36
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SimThyr has been updated to version 3.3.3. This bug-fix release addresses two issues affecting the editor for structure parameters. SimThyr 3.3.3 is available from http://simthyr.sf.net for Mac OS X, Windows and Linux. J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. med. Johannes W. Dietrich -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://www.thyreologie.com.de -- WWW: http://www.uk.rub.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2014-11-18 21:01:39
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SimThyr has been released in version 3.3.2. This bug fix release resolves some GUI-related issues with Windows XP and Mac OS X 10.10 Yosemite, and the speed of the simulator thread has been optimized. Furthermore, it is the first version using the modified code-signing algorithm for Mac OS X Mavericks and Yosemite. SimThyr 3.3.2 is available from http://simthyr.sf.net for Mac OS X, Windows and Linux. J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. med. Johannes W. Dietrich -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://www.thyreologie.com.de -- WWW: http://www.uk.rub.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2014-07-26 21:07:32
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SimThyr 3.3.1 has been released. This is a bug fix release that addresses several stability issues affecting file handling, two-way sensitivity analysis and GUI functionality. The new version that is recommended for all users of SimThyr is available from http://simthyr.sf.net . J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://www.thyreologie.com.de -- WWW: http://www.uk.rub.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2014-05-24 21:45:30
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On the occasion of the World Thyroid Day we have released SimThyr 3.3. The new version introduces significant new features, first of all support for two-way sensitivity analysis. This technique allows for studying the combined effect of two structural parameters on a behavioural parameter (i.e. hormone level). Additionally, SimThyr 3.3 adopts version handling for scenario files, an option to switch off the circadian TRH rhythm and more flexible handling of units of measurement based on PUMA Repository, Last but not least some bugs have been fixed. SimThyr 3.3 is available from http://simthyr.sf.net for Mac OS X, Windows and Linux. J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Oberarzt / Consultant Endocrinologist -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://www.thyreologie.com.de -- WWW: http://www.uk.rub.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2014-02-08 18:33:10
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On January 28th, 2014 the berliOS portal announced the closure of its highly frequented development platform for April 30th, 2014. Unfortunately, this also affects the German mirror of the SimThyr project that will be unavailable as of this date. The US mirror at sourceforge.net continues to be available, however. Please update your bookmarks and links to http://simthyr.sf.net . J. W. Dietrich -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://www.thyreologie.com.de -- WWW: http://www.uk.rub.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-10-14 19:06:28
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SimThyr has been published in version 3.2.4. This is a hot-fix release
that addresses the tracker items #18 ("Scenario files are not
correctly read in") and #19 ("Windows: Text in help window too small
to be read").
SimThyr 3.2.4 is available from http://simthyr.sf.net or http://simthyr.berlios.de
for Mac OS X, Linux and Windows.
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- --
-- Dr. Johannes W. Dietrich, M.D.
-- Laboratory XU44, Endocrine Research
-- Medical Hospital I, Bergmannsheil University Hospitals
-- Ruhr University of Bochum
-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany
-- Phone: +49:234:302-6400, Fax: +49:234:302-6403
-- eMail: "j.w...@me..."
-- WWW: http://medical-cybernetics.de
-- WWW: http://www.bergmannsheil.de
-- Researcher ID: C-3498-2009
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- --
|
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From: Johannes W. D. <joh...@ru...> - 2013-09-13 21:32:54
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We are glad to announce that SimThyr has been released in version 3.2.3 today. This is a bug-fix release that addresses numerous issues including the tracker items #12 to #17. Additionally, SimThyr 3.2.3 is the first version that has been code-signed for Mac OS X. This makes it easier to install the application on newer versions of Mac OS X, including Lion, Mountain Lion and Mavericks. SimThyr 3.2.3 is available from http://simthyr.sf.net or http://simthyr.berlios.de . -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-03-19 20:35:00
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Recently, a new paper using SPINA has been published in the Journal of Clinical Pathology. By combining in-silico modelling using SimThyr with an observation study in a large clinical sample (n=6641) it could be demonstrated that TSH levels are not unambiguously coupled to FT4 levels. To add even more complexity, GT values in different ranges were associated with a different influence of structure parameters on TSH levels in sensitivity analysis. These observations question the log-linear standard model of thyroid homeostasis and suggest that a hierarchically structured model of the hypothalamic pituitary thyroid interaction may be a more appropriate description of pituitary thyrotroph physiology. The results of this study are of considerable importance for diagnostic evaluation of thyroid homeostasis, since they demonstrate that a pure TSH-centric approach may be inadequate for diagnosis of thyroid function in some, if not most, affected patients. Abstract: Aims: Understanding the exact relationship between serum thyrotropin/ thyroid stimulating hormone (TSH) and free thyroxine (FT4) is a prerequisite for improving diagnostic reliability and clinical decision making. Methods: We (1) retrospectively studied the relationship between TSH and FT4 in a large unselected clinical sample (n=6641) of primary hypothyroid, euthyroid and hyperthyroid subjects, and (2) applied a mathematical model of thyroid hormone feedback control to assess the relation between structural parameters and TSH levels in the different functional states. Results: When separately analysing total sample and untreated subjects, the correlation slope for logTSH versus FT4 for hypothyroid subjects was significantly different from that of the euthyroid panel and hyperthyroid subjects (the latter being compromised by reaching the TSH assay's lower detection limit). As trends between functional states changed, each functional segment appeared to become differently regulated. Theoretical modelling and sensitivity analysis revealed that the influence of various structural parameters on TSH levels also depends on the overall function of the feedback loop. Conclusions: Our data suggest that the states of hypothyroidism, euthyroidism and hyperthyroidism can be regarded as differently regulated entities. The apparent complexity could be replicated by mathematical modelling suggesting a hierarchical type of feedback regulation involving patterns of operative mechanisms unique to each condition. For clinical purposes and assay evaluation, neither the standard model relating logTSH with FT4, nor an alternative model based on non-competitive inhibition can be reliably represented by a single correlation comparing all samples for both hormones in one all- inclusive group. Citation and Access: Midgley JE, Hoermann R, Larisch R, Dietrich JW. [Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model.](http://jcp.bmj.com/content/66/4/335.abstract) J Clin Pathol. 2013 Apr;66(4):335-342. Epub 2013 Feb 19. [PMID 23423518](http://www.ncbi.nlm.nih.gov/pubmed/23423518 ), [doi 10.1136/jclinpath-2012-201213](http://dx.doi.org/10.1136/jclinpath-2012-201213 ). -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-01-26 13:14:27
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A bug fix release, SimThyr 3.2.2, has been made available at sourceforge.net. As this version addresses some major issues it is highly recommended to update your existing installation. SimThyr 3.2.2 is available for Mac OS X, Windows and Linux from http://simthyr.sourceforge.net . -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-01-17 21:56:27
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A paper about medical decision making in patients receiving substitution therapy with levothyroxine was published in the European Journal of Endocrinology (2013: 168: 271-80). The paper that made use of the MiMe-NoCoDI model of pituitary-thyroid feedback control demonstrated that a pure TSH-centered approach may be insufficient for assessment of thyroid state in certain forms of heterostasis. Sensitivity analysis with SimThyr 3.2 showed a strong influence of various structural parameters on TSH secretion. Abstract: Objective. In recognition of its primary role in pituitary-thyroid feedback, thyrotropin (TSH) determination has become a key parameter for clinical decision-making. The present study evaluates the value of TSH as a measure of thyroid hormone homeostasis under T4 therapy. Design, Methods. We have examined the interrelationships between free triiodothyronine (FT3), free thyroxine (FT4) and pituitary TSH by means of 1) a retrospective analysis of a large clinical sample comprising 1994 patients either untreated or on varying doses of L-T4 and 2) independent mathematical simulation applying a model of thyroid homeostasis, together with a sensitivity analysis. Results. Over a euthyroid to mildly hyperthyroid functional range, we found markedly different correlation slopes of log TSH versus FT3 and FT4 between untreated patients and L-T4 groups. Total deiodinase activity (GD) was positively correlated with TSH in untreated subjects. However, GD was significantly altered and the correlation lost under increasing L-T4 doses. 95% confidence intervals for FT3 and FT4, when assessed in defined TSH concentration bands, differed significantly for L-T4-treated, compared to untreated patients. Higher doses were often needed to restore FT3 levels within its reference range. Sensitivity analysis revealed the influence of various structural parameters on pituitary TSH secretion including a preeminent role of pituitary deiodinase type 2. Conclusion. The data reveal disjoints between FT4-TSH feedback and T3 production that persist even when sufficient T4 apparently restores euthyroidism. T4 treatment displays a compensatory adaptation, but does not completely re-enact normal euthyroid physiology. This invites a study of the clinical consequences of this disparity. Citation and Access: Hoermann, R., J. E. M. Midgley, R. Larisch, J. W. Dietrich (2012). [Is Pituitary Thyrotropin an Adequate Measure Of Thyroid Hormone- Controlled Homeostasis During Thyroxine Treatment?](http://dx.doi.org/10.1530/EJE-12-0819 ). European Journal of Endocrinology 168(2):271-80. [doi: 10.1530/ EJE-12-0819](http://dx.doi.org/10.1530/EJE-12-0819) -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-01-10 18:03:07
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With immediate effect SimThyr is also available from Berlios, a large publicly founded open-source platform in Germany. Executables and documentation are now also hosted from http://simthyr.berlios.de. SimThyr's main repository at Sourceforge continues to be available and to be updated. Ab sofort wird SimThyr auch bei Berlios, einer großen öffentlich geförderten Plattform für quelloffene Software in Deutschland, gespiegelt. Ausführbare Dateien und Handbücher sind damit auch auf http://simthyr.berlios.de verfügbar. Das Hauptrepositorium bei Sourceforge steht weiterhin zur Verfügung und wird weiter gepflegt. J. W. D. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2013-01-01 11:03:36
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The journal of Thyroid research recently published a review article on thyroid homeostasis that extensively covers SimThyr [Dietrich, J. W., G. Landgrafe, E. H. Fotiadou. TSH and thyrotropic agonists: Key actors in thyroid homeostasis. Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012]. The peer-reviewed open-access paper is available for free via http://dx.doi.org/10.1155/2012/351864 . -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2012-11-02 22:01:25
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SimThyr has been released in version 3.2.1, featuring some bug fixes, especially for plot routines. Source code for SimThyr 3.2.1 requires Lazarus 1.0 and Free Pascal 2.6. Additional information, sources and compiled applications for different platforms are available at http://simthyr.sf.net. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |
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From: Johannes W. D. <joh...@ru...> - 2012-09-27 21:41:16
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With immediate effect SimThyr is available in version 3.2. New features include, but are not limited to, new options for data export, extended functions for sensitivity analysis and numerous error corrections. Source code for SimThyr 3.2 requires Lazarus 1.0 and Free Pascal 2.6. Additional information, sources and compiled applications for different platforms are available at http://simthyr.sf.net. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Dr. Johannes W. Dietrich, M.D. -- Laboratory XU44, Endocrine Research -- Medical Hospital I, Bergmannsheil University Hospitals -- Ruhr University of Bochum -- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany -- Phone: +49:234:302-6400, Fax: +49:234:302-6403 -- eMail: "j.w...@me..." -- WWW: http://medical-cybernetics.de -- WWW: http://www.bergmannsheil.de -- Researcher ID: C-3498-2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- |