[Rdkit-discuss] validating stereochemistry

[Tim D. <tdu...@gm...>]

I have Python code to enumerate undefined chiral centres in a molecule.
Mostly this works fine, but for some constrained structures this can
generate stereochemistry that makes no sense. For
instance consider NC1CC2CCC1C2:
[image: #1 (2).png]

These two make sense:
[image: #2.png]
[image: #3.png]

But these two don't:
[image: #5.png]
[image: #4.png]

Is there a way to filter out the invalid ones?

Thanks
Tim