RE: [PyMOL] residue replacements / modified amino acids

[Warren D. <wa...@de...>]

> 1. Is there a simple way in pymol to replace an amino acid in 
> a given structure?  If so, how can you then check (other than 
> visibly) if there are any glaring steric/electrostatic clashes?

Yes, using the mutagenesis wizard.   But no, there's no
refinement/validation possible so it isn't as useful as it otherwise might
be.

> 2. Is there a way of incorporating non-native or modified 
> amino acids into the pymol builder function?  Specifically 
> I'm thinking about fluorescently labeled amino acids, but I'd 
> assume the method is the same for any non-native amino acid.

There is no prescribed way of doing this yet.  

Cheers,
Warren