Menu
▾
▴
#1770 new child of small vegetative cells
You can get small vegetative cells by other means (i.e certain growth conditions cells are smaller and viable),
so can we have
viable small vegetative cell with premature mitosis
(analogous to the elongated cells with interphase block)
with relations to
premature mitosis
and
viable small vegetative cell
which mean annotations would propagate to both of these from the new term.
(the only gene currently annotated to both is cdc25, so when this is available we should revisit the annotations and see which can move to the new term)
need to review def of premature mitosis
wee will be syn of new term
clarification for self: just being smaller than wt isn't sufficient to call mitosis "premature"; Val will try to pin down criteria for premature
I had another note about this,
FYPO enter mitosis at reduced length (cdc2 wee1)
perhaps a synonym?
FACS analysis revealed the
presence of a significant G1 population at 19°C, consistent with
the reduced division size (Fig. 3).
PMID: 10462526
seems to be consistent with something I read earlier today.
We'll discuss later....
curs/e9505a55369a6ad9/gene/3
PMID:10462526
so if you have both
mitotic G1/S transition delay
and
viable small vegetative cell
you have
viable small vegetative cell with premature mitosis (wee)
which seems counterintuitive, but I think these cells might be small when they enter the cell cycle and never catch up. I remember Jacky saying something about this. Will look into it some more.
fussy point re this bit of the original request:
we should only annotate a phenotype if mutant cells are smaller than wild type under the same conditions; if both wt and mutant are smaller under condition x than under condition y, but are the same size as each other, don't annotate that as small cells.
OK good point. Just not confident there there are no other cases of small cell phenotypes (during quiescence for e.g.)
Is it worth waiting for the "premature mitosis" criteria before I do anything with this one? Once we can define premature mitosis better, it'll be a lot clearer what the difference is between just plain "small" and "small plus premature mitosis".
Yeah, everything I can think of my reasoning is circular.
I'm not sure where we got to with this but can you remind me why this isn't possible:
viable small vegetative cell with premature mitosis
A cellular process phenotype in which cells enter mitosis earlier, relative to cell size than normal.
(Val to do, once we have a term which is an exact synonym of 'wee', migrate all wee phenotype to this term)
This is one of the tickets that didn't make the move to GitHub. Please open a ticket there if you have questions or need further action now.