[Obo-phenotype] loss of asymmetry phenotype

[Melissa H. <mha...@uo...>]

Hi all,
I am curating a paper in which structures that are normally 
asymmetrically located are now randomly located.

In PATO:
pattern
---symmetry
------asymmetrical
------bilateral symmetry
------isometrical
------radial symmetry
------symmetrical

The phenotype I am curating:
at a certain stage, the heart is on the left side. In the mutant it is 
on the left, right, or absent.

I could use E=heart Q=asymmetrical abnormal
def:A symmetry quality inhering in a bearer by virtue of lacking symmetry.
This seems to imply that the heart is not normally asymmetrically 
located and that the phenotype lacks symmetry, which is true but not 
really the essence of the phenotype. I could also annotate up to E=heart 
Q=symmetry abnormal, but this doesn't quite capture it either.

I could also annotate it as
E=GO:0007368 determination of left/right symmetry Q=disrupted abnormal
E=heart Q=mislocalised abnormal

def: GO:0007368 determination of left/right symmetry
The establishment of an organism's body plan or part of an organism with 
respect to the left and right halves. The pattern can either be 
symmetric, such that the halves are mirror images, or asymmetric where 
the pattern deviates from this symmetry.

Should there be a new term, bilateral asymmetry? or should the bilateral 
symmetry term be updated to include asymmetry like the GO definition? 
One of these two solutions would allow an annotation where the heart and 
the fact that its normal asymmetrical location was incorrect:
E=heart Q=bilateral asymmetry abnormal
OR
E=heart Q=bilateral symmetry abnormal ---with an update to the definition.

Any other ideas?
Thanks, Melissa


-- 

Melissa Haendel, Ph.D.

 

ZFIN Scientific Curator

Zebrafish Information Network

5291 University of Oregon

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Phone: (541) 346-5108