[Obo-diffs] changes for: pathway

[<cj...@fr...>]

* Created object of type obo:TERM with id PW:0000613
* Created object of type obo:TERM with id PW:0000614
* Created object of type obo:TERM with id PW:0000615
* Populated new object PW:0000613 (macro)
  * Changed name of PW:0000613 from "PW:0000613" to "altered transforming growth factor-beta signaling pathway"
  * Set definition of PW:0000613 to "A trasforming growth factor-beta (TGF-beta) signaling pathway that deviates from what its normal course should be. Altered Tgf-b siognaling, primarily the well characterized, SMAD dependent pathway, has been implicated in numerous conditions."
  * Added definition dbxref PubMed:PMID: 16678165; 18313409 to PW:0000613
  * Added synonym "altered TGF-beta signaling pathway" to PW:0000613
  * Created link PW:0000613 -OBO_REL:is_a-> PW:0000206
  * Created link PW:0000613 -OBO_REL:is_a-> PW:0000335
  * Assigned namespace "pathway" to PW:0000613
* Populated new object PW:0000614 (macro)
  * Changed name of PW:0000614 from "PW:0000614" to "altered transforming growth factor-beta Smad dependent signaling pathway"
  * Set definition of PW:0000614 to "A transfoming growth factor-beta Smad dependent signaling pathway that deviates from what its normal course should be. Altered TGF-beta Smad dependent signaling has been implicated in vascular conditions and tumorigenesis."
  * Added definition dbxref PubMed:PMID:18313409 to PW:0000614
  * Added synonym "altered TGF-beta Smad dependent signaling pathway" to PW:0000614
  * Created link PW:0000614 -OBO_REL:is_a-> PW:0000613
  * Created link PW:0000614 -OBO_REL:is_a-> PW:0000490
  * Assigned namespace "pathway" to PW:0000614
* Populated new object PW:0000615 (macro)
  * Changed name of PW:0000615 from "PW:0000615" to "altered bone morphogenetic protein signaling pathway"
  * Set definition of PW:0000615 to "A bone morphogenetic protein (BMP) signaling pathway that deviates from what its normal course should be. Altered BMP signaling has been implicated in cardiovascular condition, pulmonary hypertension, the juvenile polyposis syndrome (JPS)."
  * Added definition dbxref PubMed:PMID:18313409 to PW:0000615
  * Added synonym "altered BMP signaling pathway" to PW:0000615
  * Created link PW:0000615 -OBO_REL:is_a-> PW:0000335
  * Created link PW:0000615 -OBO_REL:is_a-> PW:0000330
  * Assigned namespace "pathway" to PW:0000615
* Changed definition of PW:0000206 from "Transforming growth factor pathway regulates numerous cellular processes such as proliferation, differentiation, migration and cell death. The SMAD dependent pathway represents the core signaling cascade mediated by the TGF-beta superfamily. Mutations in TGF - beta family are responsible for a number of human diseases." to "Transforming growth factor-beta (TGF-beta) signaling pathway regulates numerous cellular processes such as proliferation, differentiation, migration and cell death. The SMAD dependent pathway represents the core signaling cascade mediated by the TGF-beta superfamily. Mutations in TGF - beta family are responsible for a number of human diseases."
* Deleted definition dbxref Article introduction (PubMed:TIBS, 2004, v29 (5), p267-273.) from PW:0000206
* Added definition dbxref PubMed:TIBS, 2004, v29 (5), p265-273. (PMID: 15130563 )l PMID:16678165 to PW:0000206
* Changed name of PW:0000247 from "transforming growth factor-beta signaling pathway - SMAD independent" to "transforming growth factor-beta Smad independent signaling pathway"
* Changed definition of PW:0000247 from "TGF-beta can activate signaling cascades others than the SMAD mediated ones, including MAPK pathways such as Erk, p38 and JNK. The mechanisms of MAPK pathways activation by TGF-beta are not well understood." to "TGF-beta can activate signaling cascades others than the Smad mediated ones, including MAPK pathways such as Erk, p38 and JNK. The mechanisms of MAPK pathways activation by TGF-beta are not well understood."
* Deleted synonym "SMAD independent TGF-beta signaling pathway" from PW:0000247
* Added synonym "TGF-beta Smad independent signaling pathway" to PW:0000247
* Deleted synonym "TGF-beta superfamily mediated signaling pathways" from PW:0000329
* Added synonym "TGF-beta superfamily mediated signaling pathway" to PW:0000329
* Deleted synonym "BMP signaling pathway - SMAD dependent" from PW:0000330
* Added synonym "BMP signaling pathway " to PW:0000330
* Changed definition of PW:0000335 from "Those TGF-beta superfamily mediated signaling pathways that deviate from what their normal course should be. Alone or in combination with other pathways they underlie many types of cancer, renal conditions, pulmonary hypertension." to "Those TGF-beta superfamily mediated signaling pathways that deviate from what their normal course should be. Alone or in combination with other pathways they underlie many conditions such as pulmonary hypertension and various types of cancer."
* Deleted definition dbxref Definition compiled by the PW editorial board. (PW dictionary:InHouse PW dictionary) from PW:0000335
* Added definition dbxref PubMed:PMID:18313409 to PW:0000335
* Added synonym "altered TGF-beta superfamily mediated signaling pathway" to PW:0000335
* Changed name of PW:0000490 from "transforming growth factor-beta signaling pathway - SMAD dependent" to "transforming growth factor-beta Smad dependent signaling pathway"
* Set definition of PW:0000490 to "Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized module of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors rleads to activation or repression of many genes."
* Added definition dbxref one of many reviews used to annotate and graph the pathway (PubMed:PMID: 16678165) to PW:0000490
* Added synonym "TGF-beta Smad dependent signaling pathway" to PW:0000490