#771 T cell epitope dependent biological activity assay

[James A. Overton]

The IEDB group wants to add this grouping term for our T cell assays:

• editor preferred term: T cell epitope dependent biological activity assay
• textual definition: A T cell epitope recognition assay that detects a biological process that is triggered by TCR:epitope binding events, rather than measuring the binding event itself.
• definition source for the textual definition: IEDB
• logical definition: EquivalentTo 'T cell epitope recognition assay' and (has_specified_output some ('is about' some ('process is result of' some 'MHC:epitope complex binding to TCR')))
• term editor: Bjoern Peters, Randi Vita, James A. Overton

We'll add alternative terms and an example of usage to this tracker item.

[Yu Lin]

Can you give the reference for the relation 'process is result of'?
Thanks,
Asiyah

[James A. Overton]

http://purl.obolibrary.org/obo/OBI_1110060 process is result of

[Alan Ruttenberg]

Consider using realization of disposition of (one or both of the participants in the preceding process) , or defining process is result of as chain of those. That explicitly captures the causal aspect.

Also note the similarity with the regulation relations in GO.

[bjoernpeters]

Agreed with Alan that modeling this based on dispositions would be good. Given that the relation is currently in use in a bunch of terms in OBI by the IEDB, and we currently need to add this term, we will go ahead and add it as is, and create a separate tracker item to globally replace the 'process is result of' relation. It really is a 'shortcut relation' for two processes being both in temporal order and one being caused by an event in the other.

[James A. Overton]

This term was added in r4007 as http://purl.obolibrary.org/obo/OBI_0002055 "assay measuring T cell epitope specific biological activity"