[Oae-devel] Sira's OAE-based vaccine AE study paper published now

[He, Y. <yon...@me...>]

Sira’s first-author paper is out now:

Sarntivijai S, Xiang Z, Shedden KA, Markel H, Omenn GS, Athey BD, and He Y. Ontology-based combinatorial comparative analysis of adverse events associated with killed and live influenza vaccines<http://dx.plos.org/10.1371/journal.pone.0049941>. PLoS ONE. 2012, 7(11): e49941. doi:10.1371/journal.pone.0049941.
URL: http://dx.plos.org/10.1371/journal.pone.0049941

This paper uses OAE to support the analysis of vaccine adverse events (VAEs) associated with killed or live influenza vaccines. The data used in this study came from the VAERS. Different VAE patterns, esp those associated with severe VAEs like GBS, were identified. OAE has been found to support this study significantly. From this study, OAE has been shown to be superior to MedDRA and SNOMED for AE term classification. In this paper, we have also introduced some recent updates on OAE.

After graduation from the University of Michigan Medical School Bioinformatics Program, Sira found a job in FDA as a research fellow. Some approaches introduced in this paper are being used in her current job research, which is focused on drug adverse events. For her PhD research, Sira was co-mentored by Drs. Brian Athey and me.

Sira: Congratulations for your nice paper publication, and Good luck with your continuous research in the exciting ontology-based AE research!

Oliver

Yongqun "Oliver" He, DVM, PhD
Associate Professor
Unit for Laboratory Animal Medicine
Department of Microbiology and Immunology
and Center for Computational Medicine and Bioinformatics
University of Michigan Medical School
Ann Arbor, MI 48109
Email: yon...@me...<mailto:yon...@me...>
Tel: 734-615-8231 (O)
http://www.hegroup.org/
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