MetaAnnotator

Hi everyone. NCBI has adopted a new format for its ref sequences. MetaAnnotator currently can not work on latest version of NCBI ref seq. I will update the program soon. You can use the archive version ftp://ftp.ncbi.nlm.nih.gov/genomes/archive/old_refseq/Bacteria/all.fna.tar.gz before that.


Taxonomic annotation is a critical first step for analysis of metagenomic data. Despite a lot of tools being developed, the performance (both running time and accuracy) is still not satisfactory, in particular, when a close species-level reference does not exist in the database. we propose a novel annotation tool, MetaAnnotator, to annotate metagenomics reads which outperforms all existing tools significantly when only genus-level references exist in the database.