Several bug reports of iPodder2.1 and iPodder2.2beta1
unable to update playlists etc in iTunes6.
Solution
Uninstalled iTunes6 and reinstalled iTunes5.0.0.35 and
updating of playlists is operating again with
iPodder2.2beta1.
Avoidance
Problem seems to be in the changes in iTunes6.
Until iPodder Team advise otherwise my suggestion is
DON'T install iTunes6 if you want iPodder to keep
integrating properly.
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It appears Apple have corrected the fault with integration
with the iTunes 6.0.1 - if you have been having trouble try
the upgrade to 6.0.1 and hopefully all will be well again.