#11817 NTR: nicotinic acetylcholine receptor activity

[Jane Lomax]

Hello

Do you think 'nicotinic acetylcholine receptor activity' is a legitimate term?

It's a subclass of ion-gated channel that activated_by acetylcholine OR nicotine.

Not sure if that can be expressed in OWL - otherwise could just be subclass of ion-gated channel.

Happy to add in TG if it sounds okay - let me know.

cheers

Jane

[David Hill]

Hi Jane!

I'm going to assign this to DOS for comment because he is working on synaptic transmission. Since we have the muscarinic acetylcholine receptors (GPCRs) it seems reasonable to me to have the other class.

-D

[David Osumi-Sutherland]

Looks legit - we have plenty of NT receptor activities defined like this (e.g. see AMPA & NDMA glutamate receptors). Very timely too as I'm working on NT receptor terms as part of the synapse project

[Birgit Meldal]

Hi Jane,

How does it differ from GO:0022848 acetylcholine-gated cation channel activity? Maybe it just needs a synonym or name change?

I'm currently making all the Ach receptor complexes and use the following synonyms for the complexes:

GO:0005892 acetylcholine-gated channel complex
EXACT synonym: nicotinic cholinergic receptor complex
EXACT synonym: nicotinic acetylcholine-gated receptor complex
EXACT synonym: nicotinic acetylcholine-gated receptor-channel complex
EXACT synonym: nicotinic acetylcholine-gated ion channel complex
EXACT synonym: nicotinic acetylcholine-gated cation channel complex

I also thought of changing the current CC term to "nicotinic acetylcholine receptor complex" to be in line with the literature. Should make that ticket for David OS, actually :)

Birgit

[David Osumi-Sutherland]

Hi Birgit,

We've moved to Github (announcement should go out later today). Can you copy your comment over onto the migrated ticket: https://github.com/geneontology/go-ontology/issues/11978

(That way, the comment will be flagged as coming from you and you'll be updated by email).

Ta,
David

[Birgit Meldal]

Copied to GH.