#11736 TPV: nucleotide-sugar metabolism

[Valerie Wood]

nucleotide-sugar metabolism is defined
The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.

and positioned under nucleotide metabolism

Nucleotide metabolism is defined
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

However,nucleotides-sugar doesn't fit the def of nucleotide (and isn't a nucleotide, its a nucleotide-sugar).

Nucleotide-sugar would probably work better biologically defined as the activated form of a monosaccharide

[David Osumi-Sutherland]

I thought this had been sorted out during the long negotiation with ChEBI over what counts as a sugar. Punting to David H as he is likely to know the history (as well as being a much better biochemist than I'll ever be.)

[David Hill]

Hi Val,

I put a request in the ChEBI SF tracker to look at the parentage of nucleotide conjugate.

-D