Textbook gluconeogenesis in humans consumes energy directly (ATP is used to phosphorylate intermediates) and indirectly (NADH is consumed to reduce intermediates). Also, the only product is glucose itself and under the physiological conditions in which gluconeogenesis is favored, the only metabolic fate open to that glucose is export from the producing tissue (mostly liver) to be catabolized by consumer tissues like parts of the brain and red blood cells. On both these counts, the human process looks like a poor fit to that parent. The life styles of yeasts and plants are entirely different so this relationship may well make sense there - I don't know. Can it be salvaged with a taxon constraint?
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Hi Val,
Assigning this one to David H as he has the relevant expertise and has been working on gluconeogensis.
Cheers,
David
Textbook gluconeogenesis in humans consumes energy directly (ATP is used to phosphorylate intermediates) and indirectly (NADH is consumed to reduce intermediates). Also, the only product is glucose itself and under the physiological conditions in which gluconeogenesis is favored, the only metabolic fate open to that glucose is export from the producing tissue (mostly liver) to be catabolized by consumer tissues like parts of the brain and red blood cells. On both these counts, the human process looks like a poor fit to that parent. The life styles of yeasts and plants are entirely different so this relationship may well make sense there - I don't know. Can it be salvaged with a taxon constraint?
Thanks Peter. I will reject this one.
-D