#10701 late endosome to lysosome transport

[Paul Denny]

new term request: late endosome to lysosome transport
with:
Definition: The directed movement of substances from late endosomes to the lysosome.
Child to: GO:0007041 lysosomal transport
AND
Child to: GO:0016197 endosomal transport
PMID: 23949442
The most similar term already existing is GO:0045324 late endosome to vacuole transport
Because in definition states: “This pathway is analogous to endosome to lysosome transport. "
But this term was written for yeast and it is not suitable for human cells, because the 'late' endosome is structurally different to the endosome:
GO:0005770
late endosome
Definition: A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organising center

I'd like to apply this term to lrrk (drosophila - Q9VDJ9) and Snapin (mouse - Q9Z266)

[Chris Mungall]

Hi Paul, you should be able to do this in TG

[David Osumi-Sutherland]

The relevant TG template is: cc_transport_from_to.

Let me know if you have any problems.

• David

[Paul Denny]

Thanks David - will try term genie

[David Osumi-Sutherland]

Added successfully in TG.