#1087 UniProtKB-KW:KW-0523 cell death mappings

[Valerie Wood]

I noticed that GARS
http://www.uniprot.org/uniprot/P41250
Glycine--tRNA ligase

has Keyword "cell death"

The GO cell death process term should be used for processes which initiate cell death (apoptosis, programmed cell death, etc), rather than genes which are "essential" for viability.
(Admittedly this isn't very clear from the term name)

Val

[rach_huntley]

• Description has changed:

Diff:

--- old
+++ new
@@ -1,4 +1,3 @@
-
 I noticed that GARS
 http://www.uniprot.org/uniprot/P41250
 Glycine--tRNA ligase

• Group: GOA --> UniProt

[Valerie Wood]

still has KW "cell death" will resub to UniProt

[rach_huntley]

GO:cell death was mapped to KW:neurodegeneration. I have removed this mapping as neurodegeneration is a disease state and, as you point out, cell death should only be used for those proteins that are involved in initiation of cell death rather than those which cause disease in a mutated form.

[Chris Mungall]

Consider mapping to MP:0002229 ! neurodegeneration

On 29 Sep 2014, at 1:04, rach_huntley wrote:

GO:cell death was mapped to KW:neurodegeneration. I have removed this
mapping as neurodegeneration is a disease state and, as you point out,
cell death should only be used for those proteins that are involved in
initiation of cell death rather than those which cause disease in a
mutated form.

---

[annotation-issues:#1087] UniProtKB-KW:KW-0523 cell death
mappings

Status: open
Group: UniProt
Created: Mon Sep 02, 2013 08:38 PM UTC by Valerie Wood
Last Updated: Fri Sep 26, 2014 05:11 PM UTC
Owner: nobody

I noticed that GARS
http://www.uniprot.org/uniprot/P41250
Glycine--tRNA ligase

has Keyword "cell death"

The GO cell death process term should be used for processes which
initiate cell death (apoptosis, programmed cell death, etc), rather
than genes which are "essential" for viability.
(Admittedly this isn't very clear from the term name)

Val

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