I do like the idea that stats like Str, Dex, and Manna for example all increase with exp,
But would like to see spells and weapon enchantments be able to damage them directly.
And these losses while  detrimental would not be permenant.
The immeadiate effect of:say Str loss during battle would to be suddenly unable to use the equipped weapons, armour ,etc that have Str level as a prerequesite. and they would rermain unusable untill the Str is brought back up.

And  the introduction of a new weapons class{ Returning weapons} things like Doomarangs and specially enchanted axes, spears , hammers. and knives. these all are thrown and Return to to the thrower.