#89 NTR: myocardial necrosis

[Ceri]

Necrosis of heart muscle. Result of myocardial infarction.
Tissue changes that occur in the myocardium after myocardial infarction are related to the extent to which the cells have been deprived of oxygen. Total deprivation results in an area of infarction, in which the cells die and the tissue becomes necrotic. Necrosis in this area is evident within 5 to 6 hours after the occlusion.

http://medical-dictionary.thefreedictionary.com/myocardial+necrosis

[Elvira Mitraka]

Hello Ceri,

could you please point me to the paper you are curating? Right now 'myocardial necrosis' seems to be beyond the scope of DO.

Best,
Elvira

[Anonymous]

Zebrafish papers model the infarction and the necrosis that happens
in the tissue.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&dopt=Abstract&term=22546770

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&dopt=Abstract&term=22461067

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&dopt=Abstract&term=25853735

At 03:06 PM 7/9/2015, you wrote:

Hello Ceri,

could you please point me to the paper you are curating? Right now
'myocardial necrosis' seems to be beyond the scope of DO.

Best,
Elvira

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http://sourceforge.net/p/diseaseontology/feature-requests/89[feature-requests:#89]
NTR: myocardial necrosis

Status: open
Group: Next Release (example)
Created: Wed Jul 08, 2015 07:20 PM UTC by Ceri
Last Updated: Wed Jul 08, 2015 07:20 PM UTC
Owner: nobody

Necrosis of heart muscle. Result of myocardial infarction.
Tissue changes that occur in the myocardium after myocardial
infarction are related to the extent to which the cells have been
deprived of oxygen. Total deprivation results in an area of
infarction, in which the cells die and the tissue becomes necrotic.
Necrosis in this area is evident within 5 to 6 hours after the occlusion.

http://medical-dictionary.thefreedictionary.com/myocardial+necrosishttp://medical-dictionary.thefreedictionary.com/myocardial+necrosis

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[Elvira Mitraka]

Hello Ceri,

thank you for the articles. No matter where and how I looked at 'myocardial necrosis', it cannot be classified as a disease, it is the result of a process.
In our latest version of DO (2833) we have an updated definition for the term 'myocardial infarction': "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." (PMID:17951287)

I hope you can work with that.

Best,
Elvira