I am a big fan of BibDesk. I have recently tried out the program Papers which has two features which I would love for BibDesk to have: (1) I could drop a PDF and manually click on parts of the PDF to be edited into the reference. (2) It makes a copy of the PDF into a directory so that I only need BibDesk for having all my PDFs stored aways safely.
Please contact me, the current email address can be found at http://www.jan-peters.net .
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For (1) you can use the detail editor drawer, view the pdf as text.
Also (2) is already supported through AutoFile.