Pymunk is a easy-to-use pythonic 2d physics library
Easy to use Python library for creating 2D arcade games
ZED OS the clone of Windows XP
Test project with a 2D platform game developing in Godot 3.1
Pygrid is an open-source and cross-platform pygame/python 2D engine.
Cross platform 2D game creation framework with Python bindings
Access to Irrlicht Engine SDK from assembler, C, Python, Basic, Pascal