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Porcupine is an open-source Python based web application server that provides front-end and back-end revolutionary technologies for building modern data-centric Web 2.0 applications.
Innoconda is a way to automate Inno Setup with Python. It provides a simple Python API for making Inno Scripts and running the Inno Compiler, ISCC.exe, to turn them into packages. Innoconda lets you customize just what's important, and build an installer.
PlugBoard is an Application Framework made in Python built on top of setuptools and zope interfaces which help the developer create a plugin-based application.
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QA Assistant is a GNOME-Python program that aids in Quality Assurance. It creates a graphical checklist from an XML description. A reviewer fills in the checklist and then the program outputs a gpg-signed review for submittal to a tracking system.
A simple and fast way to generate API documentation for Python source code. (text, XML, LaTeX, DocBook, etc) RealDoc does not require modules to be imported, so no hassle with non-running source trees.
Linderdaum Engine is an open source purely object-oriented 3D gaming engine written in C++. It is designed to be an integrated solution for the development of interactive 3D applications, for game, industrial and scientific visualization.
Luke is a Software Development Toolkit with a source code browser and tools for managing software development projects that may be missing from the typical IDE.
...The design of classes is done graphically, by means of a code similar to UML. It includes an inverse engineering option, that is, from Python scripts, classes and relationships are identified and represented graphically.
Biz is a WSGI-compatible web application framework written in Python. It aims to be a platform for easily developing secure and internationalized web applications.
YABT is a context sensative string manipulation library. YABT currently can be used for Braille translation, but it is possible to put it to other uses such as preparation of text to be spoken by speech synthesisers.