2D game creation software
Pygrid is an open-source and cross-platform pygame/python 2D engine.
The Flixel Power Tools are a set of plug-ins for Flixel 2.5+
Cross platform 2D game creation framework with Python bindings
StarlingPunk is a framework built on top the Starling library
Access to Irrlicht Engine SDK from assembler, C, Python, Basic, Pascal