NVIDIA Isaac Sim is an open-source application on NVIDIA Omniverse
Virtual Screening software for Computational Drug Discovery
Multi-Joint dynamics with Contact. A general purpose physics simulator
An advanced network simulator to design and configure virtual networks
FEATool Multiphysics is an easy-to-use FEA and CFD Simulation Toolbox
MzDOCK is A Virtual Screening Tool For Drug Discovery Research
... the open-source glide computer
Software for calibration of hyperelastic constitutive models
Virtual X-Ray Imaging Library on GPU
Automated SMILES-to-optimized 3D molecular structure converter
Software for electromagnetic simulation
Open Source Planar Linkage Mechanism Simulation and Synthesis Software
OpenNum lets you distribute solvers with a nice graphical interface
The Open-Source Virtual Clinical Trial Project
Real-time interactive 3D graphics API for scientific simulations
Application Integration for HPC Multiphysics
A framework for simulating open quantum dynamics
A multi-modeling and simulation environment to study complex systems
Simulate high power rocket flights with splash down plots
Open Knowledge on engineering development.
An Open source Analysis and SImulation Toolbox for Fuel Cells
Distributed Computing with JavaScript
walterbot: Virtual presence device www controlled with a raspberrypy