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Genome modeling and design across all domains of life
Evo 2 is a DNA language model system designed for long-context genome modeling and biological sequence design across all domains of life. The project models DNA at single-nucleotide resolution and supports context windows of up to one million base pairs, which places it in a class of models built for very large genomic reasoning tasks.
Yggdrasill is a 3D phylogenetic tree visualization software based on the Unity 5 engine. Intended for educational and scientific purposes this demonstration release allows to display and explore evolutionary relationships between different terrestrial vertebrate species.
Currently available features include procedural tree generation of evolutionary data provided by the Tree of Life (ToL) Web Project (http://tolweb.org/tree/), full three dimensional camera controls as well as a web...
BayesRate is a program to estimate speciation and extinction rates from dated phylogenies in a Bayesian framework.
The methods are described in:
Silvestro, D., Schnitzler, J. and Zizka, G. (2011) A Bayesian framework to estimate diversification rates and their variation through time and space. BMC Evolutionary Biology, 11, 311
Silvestro D., Zizka G. & Schulte K. (2014) Disentangling the effects of key innovations on the diversification of Bromelioideae (Bromeliaceae). Evolution, 68, 163-175.
Analyze and visualize coupled residues and their networks in proteins
xPyder is a PyMOL plugin to analyze and visualize on the 3D structure dynamical cross-correlation matrices (DCCM), linear mutual information (LMI), communication propensities (CP), intra- and inter-molecular interactions (e.g. PSN), and more, to produce highly customizable publication-quality images. xPyder identifies networks (using concepts from graph theory, such as hubs and shortest path searching), compares matrices and focuses the analysis on relevant information by filtering the data using a modular, user-expandable plugin system that takes advantage of structural and dynamical information, contributing to bridge the gap between dynamical and mechanical properties at the molecular level.
EVO is a simulation platform for co-evolving the morphology and the behavior of 3D artificial agents in a complex environment. This project directly follows the original work of Karl Sims. It puts together complex creatures, a GA & Open Dynamics Engine.
It's a program for calculating and visualizing evolutionary processes of cells in multidimensional spaces. Many cellular properties are involved (vitality, lifespan, ethnicity, growth medium), affected by mutation and accidental influences.
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