sfunctioner is a GUI wizard written in PyQt for creating Matlab Simulink sfunctions quickly and efficiently. It helps creating a fully functional sfunction within a few minutes.
pyComPic is a GUI (Graphical User Interface) for picprog, sdcc and gpasm written in Python. It uses pyGTK and GTK2 for the interface. It's a good choice if you want to avoid the command line. It works with all PIC programmers supported by picprog
A simple GUI frontend for the Microchip pk2cmd program written in python. At the minute it only supports writing. I plan to add reading and maintainance (renaming pickit2 devices, updating firmware) features soon.