Open Source Pascal Medical Software

SPINA is software for the rapid, reliable and accurate determination of constant structure parameters of endocrine feedback control systems. It is a class of static function tests that require nothing more than steady-state concentrations of hormones or metabolites obtained in vivo. The first version of this cybernetic approach had been developed for the evaluation of the functional status of the thyroid gland, i.e. thyroid's secretory capacity (gain of thyroid, GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD). A second version has been established for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor amplification (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI). Both implementations of SPINA have been validated in more than 50 clinical studies based on large cohorts.

SimulAdren is a simulation program for the hypothalamus-pituitary-adrenal axis (HPA feedback control). It is based on a nonlinear MiMe-NoCoDI model and uses the CyberUnits Bricks class library.

Avian Freeware Suite (AFS) provides two things: Developers with libraries for Java Swing Widgets, XML handling, Fortran95 and Pascal; End users (Medical students, doctors, scientists) with productivity tools they can use (quizzes, XML databasing & PDF)

BMI Wizard calculates the body mass index (BMI) from weight and size and vice versa.

Diktyologia is software for investigating complex systems with advanced methods of network theory. The package allows for analysing statistical properties of directed intercausal networks that are represented in form of cy.prus XML files.

Collection of algorithms for computational statistics in life sciences

ROC.KIT is an application for health sciences that automatically calculates ROC curves (receiver operating charateristic plots) from continuous medical data like laboratory results.

SimThyr is a continuous simulation program for the human pituitary-thyroid feedback control system. Applications of this program cover research, including development of hypotheses, and education of students in biology and medicine, nurses and patients.

SimulaBeta is a simulation program for insulin-glucose feedback control. It is based on a nonlinear MiMe-NoCoDI model.

Tempomat is software that supports statistical analysis of time series in the life sciences.

Calculator software helping to determine L-T4 and L-T3 substitution dosage according to the algorithms provided by the European Thyroid Association (ETA).

cy.prus is a cross platform simulation environment for medical cybernetics and systems biology. Its purpose is to provide both a facility for simulating life and a GUI for easily constructing biological information processing structures based on XML.