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Supybot Twitter plugin, using OAuth. Requires oauth2 & simplejson
As of March 2013, Twitter will be removing API 1.0 and supytweet will likely cease to work.
For an up to date twitter plugin see ProgVal's Twitter on his github; https://github.com/ProgVal/Supybot-Plugins
Full featured, modular IRC bot built from scratch in Python, similar to eggdrop. The internal object oriented IRC library is designed to be both flexible and extensible and is easily separated from the rest of the bot for other projects.