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The MUSCLE system is a fast, portable, flexible client-server system for distributed applications. Clients send BMessage-like PortableMessages to each other either directly or via a centralized server (with built-in database and 'live query' support).
Supybot Twitter plugin, using OAuth. Requires oauth2 & simplejson
As of March 2013, Twitter will be removing API 1.0 and supytweet will likely cease to work.
For an up to date twitter plugin see ProgVal's Twitter on his github; https://github.com/ProgVal/Supybot-Plugins
planimo is an instant messaging system planned for lan chats. It support file transfers between users, can emit beeps whene new message arrive and integrate well in gnome desktop! It works on windows too
A python XML aware asynchronous multi-user server. Allows Macromedia Flash clients to connect to this server via actionscript, to create rooms, subrooms ... to chat in private or in a room, to protect a room, to play an internet multiplayer flash games
Concurrence is a networked file editing program that enables multiple people to modify a document simultaneously. It is written entirely in Python, and uses the wxPython library for the GUI and the Twisted library for networking.
JabSync is a program intended to synchronize the rosters of two (or more) distinct Jabber accounts.
It is written in Python and uses the jabberpy library.
Full featured, modular IRC bot built from scratch in Python, similar to eggdrop. The internal object oriented IRC library is designed to be both flexible and extensible and is easily separated from the rest of the bot for other projects.
<b>Msn4Lin</b> is a messenger client for X. At the moment available in Tcl/Tk (easy installation, but with failures) or C++ with <a href=/projects/xlion/>XLion</a> (difficult installation, but more stable). It supports plugins, skins, multilanguage, ...
PySocks - a platform independent SOCKS proxy written in Python
Do you share an DSL or cable connection between several computers? With PySocks you'll be able to use all features of ICQ, MIRC, Napster and such again!
A peer-to-peer chat program that uses public key encryption (via Gnu Privacy Guard) to keep your conversations from the eyes of packet sniffers (*Cough* Carnivore *Cough*)