A retro game engine for Python
GemRB is a portable open-source implementation of the Infinity Engine
A world editor for HGE game engine written in python and uses OpenGL.
Cross platform 2D game creation framework with Python bindings
Open source, moddable game engine for the "Polygon Love 2" game
Access to Irrlicht Engine SDK from assembler, C, Python, Basic, Pascal
Tikal Online - 3D MMORPG (Torque/Python)
Make games with Lego-like building blocks