Pygrid is an open-source and cross-platform pygame/python 2D engine.
CometZ is a simple side scrolling space shooter
Super Mario Python Final
AddMeFast Auto-Clicker!
A graphics engine + toolkit.
Sprite Font Creator
Python/Pygame Game-Building Framework
Cross platform 2D game creation framework with Python bindings
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Access to Irrlicht Engine SDK from assembler, C, Python, Basic, Pascal
Open Source Virtual World and MMOG Development Platform
Python Killboard Platform for EVE Online
Invaders like game, written in Python with Curses... :)