Python/Pygame Game-Building Framework
A Space Master 2nd Edition Character Generator
A 2D Elite-style game written in Python 3.2.
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Open Source Virtual World and MMOG Development Platform
6DOF zero-g claustrophobic space shooter
Conway's Game of Life and Turmites Combined!
Python Killboard Platform for EVE Online
Scriptable GTK based Python MUD Client
Invaders like game, written in Python with Curses... :)