One framework for creating powerful cross-platform games
PyCAPGE - Python Classic Adventure Point and Click Game Engine
2D Game Engine
Multidocument automation by templates - for sphinx, mkdocs, epydoc ...
Pygrid is an open-source and cross-platform pygame/python 2D engine.
A truly extensible cross-platform game engine
An extensible development framework for roleplay games.
Open Source Virtual World and MMOG Development Platform
Game framework on top of Python, Panda3D and Twisted
The Lambda-Engine is a cross platform game engine.
Make games with Lego-like building blocks