The TuxCap Games Framework is a GNU/Linux and Mac OSX port of the PopCap Games Framework used for 2D game development. It comes with PyCap Python bindings, a fast 2D physics engine, a particle engine, widgets and many documented examples.
Cross platform 2D game creation framework with Python bindings
FIFE is a cross platform 2D game creation framework written in C++ with Python bindings. It's designed to be flexible enough to support a wide variety of 2D game types but specializes in 2D isometric type views.
Linderdaum Engine is an open source purely object-oriented 3D gaming engine written in C++. It is designed to be an integrated solution for the development of interactive 3D applications, for game, industrial and scientific visualization.
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Spineless is a generic cross-platform 3D game engine implemented in Python. Focus is on flexibility, clean design and ease of use, not pure speed or bleeding edge graphics.