a parametric 3D CAD modeler
Open-Source Multiphysics FEA (FEM) Package
Free and open source pattern design software
LibrePLM integrates CAD editors in Odoo / LibrERP
cppcam is a 3D CAD app for drafting G-Code toolpaths for CNC Routers
An Open source Analysis and SImulation Toolbox for Fuel Cells
2.5D CAD CAM emphasis on CAM and toolpaths
CNC machine code generation for 3D models
ALST is a CAD for all imaginable logic systems (binary, ternary, etc)