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Probabilistic natural mapping for gene based association study.
PALM is a software that conducts gene-based association analysis. PALM exploits HiddenMarkov Models (HMM) to capture the inner genomic structures. Then, unique gene features (termed "palm prints") are extracted for each gene set by calculating the natural gradient. Then palm-prints are tested with chi-square significance test.
The General HiddenMarkov Model Library (GHMM) is a C library with additional Python bindings implementing a wide range of types of HiddenMarkov Models and algorithms: discrete, continous emissions, basic training, HMM clustering, HMM mixtures.
TransGeneScan is a gene finding tool for metatranscriptomic sequences
...TransGeneScan is no longer maintained in SourceForge. Please find the latest version in Github.
TransGeneScan is a gene finding tool for Metatranscriptomic sequences. TransGeneScan incorporates strand-specic hidden states, representing coding sequences in sense and anti-sense strands on transcripts in a HiddenMarkov Model similar to the one used in FragGeneScan (http://fraggenescan.sourceforge.net/), and can predict a sense transcript containing one or multiple genes (in an operon) or an antisense transcript.
Create portable, flexible domain drawings of protein sequences
...ProtDraw creates flexible, easily-interpretable and portable illustrations of the domain structures of input sequences. ProtDraw is accompanied by makeProtDraw, a helper program which runs hmmer3 on a specified set of hiddenMarkov models and formats results for ProtDraw. Highest-scoring domains are selected in cases of overlap. Domain drawings may be organized by sequence classification.
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It is often necessary to assign a series of discrete values to continuosly variable data sequenced by time, position, etc., thereby parsing the data into fewer and larger segments of variable width. The 'segment' utility takes an input data stream as a HiddenMarkov Model and applies the Viterbi algorithm to find the most likely segmentation path through the data.
RefineHMM refines an original hiddenMarkov model (HMM) to find an optimal fit
against the evolutionary group that the HMM models, and it does this using
through iterative database searches and incremental subsequent adaptation of
the seed set.
D-finder is a bioinformatic search algorithm for the identification of D-sites in JNK interacting proteins. The algorithm is a combination of pattern matching and a hiddenmarkov model (HMM) based on a training set of known JNK D-sites.
Conrad is both a high performance Conditional Random Field engine which can be applied to a variety of machine learning problems and a specific set of models for gene prediction using semi-Markov CRFs.
HmmSDK is a hiddenMarkov model (HMM) software development kit written in Java. It consists of core library of HMM functions (Forward-backward, Viterbi, and Baum-Welch algorithms) and toolkits for application development.