RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
ATpy (Astronomical Tables in Python) is a Python module aimed at dealing with tables of astronomical data with a common API. To date, the following formats are supported: FITS, VO, and IPAC tables, and SQLite, MySQL, and PostgreSQL databases