Python Agentic AI Tools

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Browse free open source Python Agentic AI Tools and projects below. Use the toggles on the left to filter open source Python Agentic AI Tools by OS, license, language, programming language, and project status.

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  • 1
    OpenSquilla

    OpenSquilla

    Token-Efficient AI Agent with same budget, higher intelligence density

    OpenSquilla is a token-efficient microkernel AI agent runtime designed for CLI, web UI, and chat-based workflows. It routes each turn through a shared loop that can select lower-cost models when appropriate while preserving tool dispatch, retries, memory, and decision logging. The project supports multiple LLM providers through a pluggable provider layer, making it adaptable to different model ecosystems. It includes persistent memory, built-in web search, on-device embeddings, and sandboxing for safer execution. OpenSquilla is designed for users who want stronger agent capabilities without wasting tokens on every interaction. Its main value is combining cost-aware routing, durable context, and multi-channel agent execution in one local runtime.
    Downloads: 10 This Week
    Last Update:
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  • 2
    Scientific Agent Skills

    Scientific Agent Skills

    A set of ready to use Agent Skills for research, science, engineering

    Scientific Agent Skills is an open-source collection of ready-to-use agent skills designed to turn AI coding assistants into stronger research, science, engineering, and analysis partners. It supports any AI agent compatible with the Agent Skills standard, including tools such as Cursor, Claude Code, Codex, and Gemini CLI. The repository includes 135 skills across scientific domains such as genomics, cheminformatics, clinical research, medical imaging, machine learning, physics, materials science, geospatial analysis, and scientific writing. Each skill provides curated documentation, examples, best practices, and integration guidance so agents can execute complex workflows more reliably. It is especially useful for researchers who need AI assistance with databases, Python libraries, literature review, data analysis, and scientific communication. The project also emphasizes extensibility, security review, and practical installation through npx or GitHub CLI.
    Downloads: 10 This Week
    Last Update:
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  • 3
    Agent Zero

    Agent Zero

    Agent Zero AI framework

    Agent Zero is not a predefined agentic framework. It is designed to be dynamic, organically growing, and learning as you use it. Agent Zero is fully transparent, readable, comprehensible, customizable and interactive. Agent Zero uses the computer as a tool to accomplish its (your) tasks. Agents can communicate with their superiors and subordinates, asking questions, giving instructions, and providing guidance. Instruct your agents in the system prompt on how to communicate effectively. The terminal interface is real-time streamed and interactive. You can stop and intervene at any point. If you see your agent heading in the wrong direction, just stop and tell it right away. There is a lot of freedom in this framework. You can instruct your agents to regularly report back to superiors asking for permission to continue. You can instruct them to use point-scoring systems when deciding when to delegate subtasks. Superiors can double-check subordinates' results and disputes.
    Downloads: 9 This Week
    Last Update:
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  • 4
    Open-AutoGLM

    Open-AutoGLM

    An open phone agent model & framework

    Open-AutoGLM is an open-source framework and model designed to empower autonomous mobile intelligent assistants by enabling AI agents to understand and interact with phone screens in a multimodal manner, blending vision and language capability to control real devices. It aims to create an “AI phone agent” that can perceive on-screen content, reason about user goals, and execute sequences of taps, swipes, and text input via automated device control interfaces like ADB, enabling hands-off completion of multi-step tasks such as navigating apps, filling forms, and more. Unlike traditional automation scripts that depend on brittle heuristics, Open-AutoGLM uses pretrained large language and vision-language models to interpret visual context and natural language instructions, giving the agent robust adaptability across apps and interfaces.
    Downloads: 9 This Week
    Last Update:
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    AIHawk

    AIHawk

    AIHawk aims to easy job hunt process by automating job applications

    AIHawk is an AGPL‑licensed AI agent focused on automating job applications. It scrapes job listings from corporate sites (or LinkedIn in forks) and uses LLMs to generate tailored applications, streamlining the process across multiple platforms—dubbed “revolutionary” by mainstream tech outlets.
    Downloads: 8 This Week
    Last Update:
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  • 6
    AgentUniverse

    AgentUniverse

    agentUniverse is a LLM multi-agent framework

    AgentUniverse is a multi-agent AI framework that enables coordination between multiple intelligent agents for complex task execution and automation.
    Downloads: 8 This Week
    Last Update:
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  • 7
    Android Use

    Android Use

    Automate native Android apps with AI using accessibility APIs

    android-action-kernel is an open source Python library designed to let AI agents control and automate native Android applications running on real devices or emulators. It fills a gap in automation tooling by focusing on mobile-first workflows where traditional browser or desktop-based automation doesn’t work; such as logistics, gig work, field operations, and other industries reliant on phones or tablets. The project works by using Android’s accessibility API to extract structured UI state (as XML) from the device, which is then fed to a large language model (LLM) like OpenAI’s models for decision-making, and actions are executed via the Android Debug Bridge (ADB). This approach bypasses expensive vision-based models and provides faster, cheaper automation with fine-grained interaction capabilities (for example, tapping buttons, typing text, navigating screens).
    Downloads: 8 This Week
    Last Update:
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  • 8
    GPT Researcher

    GPT Researcher

    LLM based autonomous agent that does online comprehensive research

    Say Hello to GPT Researcher, your AI agent for rapid insights and comprehensive research. GPT Researcher is the leading autonomous agent that takes care of everything from accurate source gathering to organization of research results.
    Downloads: 8 This Week
    Last Update:
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  • 9
    VulnClaw

    VulnClaw

    Based on AI Agent + MCP toolchain + penetration Skill orchestration

    VulnClaw is an AI-powered penetration testing agent that turns natural language security goals into structured testing workflows. It combines LLM agents, MCP toolchains, penetration testing skills, and command-line automation to support authorized security assessments. The project can guide information gathering, vulnerability discovery, validation, and report generation while keeping the workflow organized through sessions and tools. Its newer architecture uses a goal-driven solving engine instead of a fixed-round loop, helping the agent stop when the goal is reached, the search space is exhausted, or a safety budget is met. It also includes evidence checks designed to reduce hallucinated conclusions by requiring real tool output before accepting key findings. VulnClaw is intended for authorized testing, CTFs, security education, and controlled red-team environments.
    Downloads: 8 This Week
    Last Update:
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  • 10
    Cua

    Cua

    Open-source infrastructure for Computer-Use Agents. Sandboxes

    Cua is an open-source command-line utility and workflow orchestrator designed to help developers define, compose, and run common tasks with a unified interface, promoting consistency and reuse across projects. It introduces a declarative syntax for specifying build scripts, automation pipelines, environment setups, and project-specific commands so contributors don’t need to memorize disparate scripts or tooling across languages and ecosystems. Cua can also manage task dependencies, handle cross-platform invocations, and simplify complex workflows into simple aliases or compound commands that are easy to share in teams. By centralizing shared commands in a structured, documented config, it helps reduce errors, accelerates onboarding of new contributors, and keeps task definitions versioned with the codebase. The CLI is typically lightweight, easy to install, and designed to integrate with existing toolchains and shells without friction.
    Downloads: 7 This Week
    Last Update:
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  • 11
    Eigent

    Eigent

    The Open Source Cowork Desktop to Unlock Your Exceptional Productivity

    Eigent is an open-source cowork desktop application designed to help you build, manage, and deploy a custom AI workforce. It enables multiple specialized AI agents to collaborate in parallel, turning complex workflows into automated, end-to-end tasks. Built on the CAMEL-AI multi-agent framework, Eigent emphasizes productivity, flexibility, and transparent system design. You can run Eigent fully locally for maximum privacy and data control, or choose a cloud-connected experience for quick access. The platform supports a wide range of AI models and integrates powerful tools through the Model Context Protocol (MCP). With human-in-the-loop controls and enterprise-ready features, Eigent balances automation with oversight and security.
    Downloads: 7 This Week
    Last Update:
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  • 12
    Khazix Skills

    Khazix Skills

    Digital Life Kazik Open Source AI Skills Collection

    Khazix Skills project is an automation framework designed to transform GitHub repositories into structured, reusable AI agent skills. It acts as a pipeline that analyzes a repository’s metadata, extracts relevant information such as README content and commit hashes, and converts it into a standardized skill format that can be integrated into agent ecosystems. The system emphasizes lifecycle management by embedding versioning, traceability, and metadata directly into generated skill files, allowing future updates and synchronization with the original repository. It also generates wrapper scripts that enable AI agents to interact with the underlying repository functionality without requiring deep manual integration. By enforcing a consistent schema, the project ensures interoperability between skills and simplifies deployment across environments. This makes it especially useful for teams building modular AI agents that rely on external tools or open-source repositories.
    Downloads: 7 This Week
    Last Update:
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  • 13
    OpenAI Python

    OpenAI Python

    The official Python library for the OpenAI API

    The OpenAI Python library provides convenient access to the OpenAI REST API from any Python 3.7+ application. The library includes type definitions for all request params and response fields, and offers both synchronous and asynchronous clients powered by httpx.
    Downloads: 7 This Week
    Last Update:
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  • 14
    OpenClaw Medical Skills

    OpenClaw Medical Skills

    The largest open-source medical AI skills library for OpenClaw

    OpenClaw-Medical-Skills is an open-source library that provides a large collection of specialized medical capabilities designed for the OpenClaw AI agent ecosystem. The project organizes domain-specific “skills” that enable autonomous agents to perform tasks related to biomedical research, healthcare analysis, and clinical data interpretation. Each skill is packaged as a modular component that can be integrated into an OpenClaw-based AI assistant, allowing the agent to perform expert-level reasoning and workflows in medical contexts. Instead of relying on general-purpose language model responses, the repository equips AI agents with structured instructions and tools tailored to medical knowledge and datasets. This modular design allows developers and researchers to build AI systems that can access specialized medical reasoning processes, retrieve relevant biomedical information, and generate structured outputs suitable for analysis or downstream processing.
    Downloads: 7 This Week
    Last Update:
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  • 15
    /last30days

    /last30days

    Claude Code skill that researches any topic across Reddit + X

    /last30days is a specialized Claude Code skill designed to research current trends and practices across Reddit, X, and the wider web from the last 30 days, synthesize that data, and produce copy-paste-ready prompts or summaries that reflect what the community is actually talking about now. Rather than returning generic model responses, it intelligently analyzes social media and community discussions to identify what’s genuinely trending or working in practice across topics ranging from prompt techniques to tool usage or cultural trends. This makes it particularly useful for prompt engineers, content creators, and developers who want up-to-date prompts and insights that align with the most recent consensus and shared best practices in fast-moving fields like AI tooling.
    Downloads: 6 This Week
    Last Update:
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  • 16
    Agent Reach

    Agent Reach

    Give your AI agent eyes to see the entire internet

    Agent Reach is a command-line tool that gives AI agents access to public internet content across multiple platforms. It is designed for agent workflows that need to read and search sources like Twitter, Reddit, YouTube, GitHub, Bilibili, and XiaoHongShu without relying on paid platform APIs. The project focuses on giving AI tools broader visibility into social, video, code, and community data through one interface. It can be useful for research agents, automation workflows, competitive monitoring, content analysis, and social listening. Agent-Reach also supports modern agent environments by exposing capabilities that can be connected into larger AI workflows. Its main value is making scattered web platforms easier for agents to query, inspect, and summarize from the command line.
    Downloads: 6 This Week
    Last Update:
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  • 17
    Bolna

    Bolna

    Conversational voice AI agents

    Bolna is an end-to-end open-source platform for building conversational voice AI agents, enabling developers to create voice-first conversational assistants efficiently.
    Downloads: 6 This Week
    Last Update:
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  • 18
    Medeo Video Generator

    Medeo Video Generator

    AI-powered video generation skill for OpenClaw

    Medeo Video Generator is an AI-driven project designed to enable advanced video processing and generation capabilities within agent-based or automation systems. It provides a “skill” module that can be integrated into AI agents, allowing them to create, edit, and manipulate video content programmatically. The project focuses on bridging the gap between language-based AI systems and multimedia outputs by enabling models to produce structured video content as part of their workflows. It supports tasks such as video generation, editing, and transformation, making it useful for applications in content creation, marketing, and automated media production. The framework is designed to be modular, allowing developers to plug video capabilities into larger AI pipelines or agent systems. It emphasizes ease of integration and scalability, enabling both simple use cases and more complex multimedia workflows.
    Downloads: 6 This Week
    Last Update:
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  • 19
    OpenAI Agent Skills

    OpenAI Agent Skills

    Skills Catalog for Codex

    OpenAI Agent Skills is an open-source repository that serves as a broad catalog of agent skills designed to extend the capabilities of OpenAI Codex and other AI coding agents. It organizes reusable, task-specific workflows, instructions, scripts, and resources into modular skill folders so that an AI agent can reliably perform complex tasks without repeated custom prompting, making agent behavior more predictable and composable. Each skill is defined with clear metadata and instructions organizing how an AI assistant should complete specific tasks ranging from project management to code generation and documentation assistance. The repository supports community contributions, allowing developers to add new skills or update existing ones to keep the catalog relevant and practical for evolving use cases.
    Downloads: 6 This Week
    Last Update:
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  • 20
    Self-Operating Computer

    Self-Operating Computer

    A framework to enable multimodal models to operate a computer

    The Self-Operating Computer Framework is an innovative system that enables multimodal models to autonomously operate a computer by interpreting the screen and executing mouse and keyboard actions to achieve specified objectives. This framework is compatible with various multimodal models and currently integrates with GPT-4o, o1, Gemini Pro Vision, Claude 3, and LLaVa. Notably, it was the first known project to implement a multimodal model capable of viewing and controlling a computer screen. The framework supports features like Optical Character Recognition (OCR) and Set-of-Mark (SoM) prompting to enhance visual grounding capabilities. It is designed to be compatible with macOS, Windows, and Linux (with X server installed), and is released under the MIT license.
    Downloads: 6 This Week
    Last Update:
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  • 21
    AI Agent Book

    AI Agent Book

    Deep Understanding AI Agents

    AI Agent Book is an open educational repository for Understanding AI Agents: Design Principles and Engineering Practice. It explains agents through the formula of a language model combined with context and tools. Ten chapters move from core concepts to context engineering, memory, RAG, knowledge graphs, MCP tools, and coding agents. Later material covers evaluation, supervised fine-tuning, reinforcement learning, self-improvement, multimodal interaction, robotics, and multi-agent cooperation. The repository includes 88 companion experiments, with more than 70 designed to run independently. Readers can access the source chapters, generated figures, code, and downloadable PDF or EPUB editions. Community translations provide versions in several languages alongside the original Chinese text.
    Downloads: 5 This Week
    Last Update:
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  • 22
    Academic Research Skills for Claude Code

    Academic Research Skills for Claude Code

    Academic Research Skills for Claude Code

    Academic Research Skills is a structured learning repository aimed at improving users’ ability to conduct rigorous academic research, particularly in technical and scientific domains. It compiles methodologies, frameworks, and best practices for literature review, critical analysis, and research writing. The project is designed as a self-guided resource, helping learners understand how to evaluate sources, synthesize information, and develop strong arguments. It likely integrates examples, templates, and conceptual explanations to bridge the gap between theory and practical research execution. The repository emphasizes skill-building rather than automation, making it especially useful for students and early-career researchers. Its overall goal is to enhance research literacy and reproducibility in academic workflows.
    Downloads: 5 This Week
    Last Update:
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  • 23
    AskUI Vision Agent

    AskUI Vision Agent

    Enable AI to control your desktop, mobile and HMI devices

    AskUI’s Vision Agent is an automation framework that allows you—and AI agents—to control real desktops, mobile devices, and HMI systems by perceiving the UI and performing actions like clicking, typing, scrolling, and drag-and-drop. It is designed for multi-platform compatibility and supports multiple AI models so you can tailor perception and decision-making to your workload. The repository presents a feature overview, sample media, and frequent release notes, which show ongoing improvements such as CORS checks and other operational tweaks. The broader AskUI documentation covers the Python Vision Agent along with suite services and inference APIs, indicating a productized ecosystem rather than a single library. Community-curated lists also recognize Vision Agent as part of the broader “GUI agents” landscape, placing it among other computer-use agents.
    Downloads: 5 This Week
    Last Update:
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  • 24
    BlenderMCP

    BlenderMCP

    Blender Model Context Protocol Integration

    BlenderMCP is a bridge that connects Blender, a 3D modeling and rendering software, with AI systems like Claude through the Model Context Protocol, enabling direct AI-driven interaction with 3D environments. It allows users to control Blender using natural language prompts, effectively turning AI into a co-creator for 3D modeling, scene construction, and asset manipulation. The system establishes a two-way communication channel between Blender and the AI, where commands can be sent and results retrieved in real time. It includes features for object manipulation, material editing, and scene inspection, giving the AI deep control over the modeling environment. The project also supports integration with external asset sources such as Sketchfab and Poly Haven, expanding the range of available resources. Additionally, it allows execution of Python scripts within Blender through AI commands, enabling advanced automation and customization.
    Downloads: 5 This Week
    Last Update:
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  • 25
    Claude Code Plugins

    Claude Code Plugins

    Intelligent automation and multi-agent orchestration for Claude Code

    Claude Code Plugins is a lightweight framework designed to define, manage, and execute AI agents in a modular and extensible way, typically focusing on orchestrating tasks using large language models and tool integrations. The project provides abstractions for building agents that can interpret instructions, execute commands, and interact with external systems in a structured workflow. It emphasizes simplicity and composability, allowing developers to define agent behaviors through reusable components rather than monolithic logic. The framework supports integration with various tools and APIs, enabling agents to perform actions such as data retrieval, automation, and decision-making processes. It is particularly useful for experimenting with autonomous or semi-autonomous systems that rely on prompt-driven logic and tool usage. The design encourages transparency and control over how agents operate, making it suitable for both prototyping and production scenarios.
    Downloads: 5 This Week
    Last Update:
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