Python Agentic AI Tools

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Browse free open source Python Agentic AI Tools and projects below. Use the toggles on the left to filter open source Python Agentic AI Tools by OS, license, language, programming language, and project status.

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  • 1
    AutoGPT

    AutoGPT

    Powerful tool that lets you create and run intelligent agents

    AutoGPT is an experimental open-source application showcasing the capabilities of the GPT-4 language model. This program, driven by GPT-4, chains together LLM "thoughts", to autonomously achieve whatever goal you set. As one of the first examples of GPT-4 running fully autonomously, AutoGPT pushes the boundaries of what is possible with AI.
    Downloads: 15 This Week
    Last Update:
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  • 2
    Agent Zero

    Agent Zero

    Agent Zero AI framework

    Agent Zero is not a predefined agentic framework. It is designed to be dynamic, organically growing, and learning as you use it. Agent Zero is fully transparent, readable, comprehensible, customizable and interactive. Agent Zero uses the computer as a tool to accomplish its (your) tasks. Agents can communicate with their superiors and subordinates, asking questions, giving instructions, and providing guidance. Instruct your agents in the system prompt on how to communicate effectively. The terminal interface is real-time streamed and interactive. You can stop and intervene at any point. If you see your agent heading in the wrong direction, just stop and tell it right away. There is a lot of freedom in this framework. You can instruct your agents to regularly report back to superiors asking for permission to continue. You can instruct them to use point-scoring systems when deciding when to delegate subtasks. Superiors can double-check subordinates' results and disputes.
    Downloads: 14 This Week
    Last Update:
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  • 3
    OpenHands

    OpenHands

    Open-source autonomous AI software engineer

    Welcome to OpenHands (formerly OpenDevin), an open-source autonomous AI software engineer who is capable of executing complex engineering tasks and collaborating actively with users on software development projects. Use AI to tackle the toil in your backlog, so you can focus on what matters: hard problems, creative challenges, and over-engineering your dotfiles We believe agentic technology is too important to be controlled by a few corporations. So we're building all our agents in the open on GitHub, under the MIT license. Our agents can do anything a human developer can: they write code, run commands, and use the web. We're partnering with AI safety experts like Invariant Labs to balance innovation with security.
    Downloads: 13 This Week
    Last Update:
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  • 4
    MindsDB

    MindsDB

    Making Enterprise Data Intelligent and Responsive for AI

    MindsDB is an AI data solution that enables humans, AI, agents, and applications to query data in natural language and SQL, and get highly accurate answers across disparate data sources and types. MindsDB connects to diverse data sources and applications, and unifies petabyte-scale structured and unstructured data. Powered by an industry-first cognitive engine that can operate anywhere (on-prem, VPC, serverless), it empowers both humans and AI with highly informed decision-making capabilities. A federated query engine that tidies up your data-sprawl chaos while meticulously answering every single question you throw at it. MindsDB has an MCP server built in that enables your MCP applications to connect, unify and respond to questions over large-scale federated data—spanning databases, data warehouses, and SaaS applications.
    Downloads: 11 This Week
    Last Update:
    See Project
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  • 5
    Notte

    Notte

    Opensource browser using agents

    Notte is an open-source browser framework that enables the development and deployment of web-based AI agents. It introduces a perception layer that transforms web pages into structured, navigable maps described in natural language, allowing agents to interact with the internet more effectively. Notte is designed for building scalable and efficient browser-based AI applications.
    Downloads: 11 This Week
    Last Update:
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  • 6
    OpenAI Python

    OpenAI Python

    The official Python library for the OpenAI API

    The OpenAI Python library provides convenient access to the OpenAI REST API from any Python 3.7+ application. The library includes type definitions for all request params and response fields, and offers both synchronous and asynchronous clients powered by httpx.
    Downloads: 10 This Week
    Last Update:
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  • 7
    c/ua

    c/ua

    c/ua is the Docker Container for Computer-Use AI Agents

    Cua is a Docker-based framework that facilitates the deployment and management of computer-use AI agents. It provides a sandboxed environment where agents can perform tasks on macOS and Linux virtual machines, supporting various AI models and ensuring safe execution. Cua is particularly useful for developers looking to test and run AI agents in controlled settings.
    Downloads: 8 This Week
    Last Update:
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  • 8
    Self-Operating Computer

    Self-Operating Computer

    A framework to enable multimodal models to operate a computer

    The Self-Operating Computer Framework is an innovative system that enables multimodal models to autonomously operate a computer by interpreting the screen and executing mouse and keyboard actions to achieve specified objectives. This framework is compatible with various multimodal models and currently integrates with GPT-4o, o1, Gemini Pro Vision, Claude 3, and LLaVa. Notably, it was the first known project to implement a multimodal model capable of viewing and controlling a computer screen. The framework supports features like Optical Character Recognition (OCR) and Set-of-Mark (SoM) prompting to enhance visual grounding capabilities. It is designed to be compatible with macOS, Windows, and Linux (with X server installed), and is released under the MIT license.
    Downloads: 7 This Week
    Last Update:
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  • 9
    Skyvern

    Skyvern

    Automate browser-based workflows with LLMs and Computer Vision

    Skyvern uses a combination of computer vision and AI to understand content on a webpage, making it adaptable to any website. Skyvern takes instructions in natural language, allowing it to execute complex objectives with simple commands. Skyvern is an API-first product. Workflows execute in the cloud, allowing it to run hundreds of workflows at the same time. Skyvern's AI decisions come with built-in explanations, providing clear summaries and justifications for every action. Support for proxies, with support for country, state, or even precise zip-code level targeting. Skyvern understands how to solve CAPTCHAs to complete complicated workflows. Support for authenticating into user accounts, including support for 2FA/TOTP. Extract data from workflows in any schema of your choice including CSV or JSON. Automate procurement pipelines, breeze through government forms, and complete workflows in any language.
    Downloads: 7 This Week
    Last Update:
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  • 10
    DB-GPT

    DB-GPT

    Revolutionizing Database Interactions with Private LLM Technology

    DB-GPT is an experimental open-source project that uses localized GPT large models to interact with your data and environment. With this solution, you can be assured that there is no risk of data leakage, and your data is 100% private and secure.
    Downloads: 6 This Week
    Last Update:
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  • 11
    Airweave

    Airweave

    Airweave lets agents search any app

    Airweave is an open-source platform that enables agents to semantically search across various applications, databases, and APIs. By transforming disparate data sources into a unified, searchable knowledge base, Airweave facilitates intelligent information retrieval through REST APIs or the MCP protocol. It's particularly useful for building AI agents that require access to structured and unstructured data across multiple platforms.
    Downloads: 5 This Week
    Last Update:
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  • 12
    ChemCrow

    ChemCrow

    Chemcrow

    ChemCrow is an AI-powered framework designed to assist in chemical research and discovery. It integrates AI models with chemical knowledge bases to provide intelligent recommendations for synthesis planning, reaction prediction, and material discovery. This tool helps automate and accelerate research in computational chemistry and drug development.
    Downloads: 5 This Week
    Last Update:
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  • 13
    Haystack

    Haystack

    Haystack is an open source NLP framework to interact with your data

    Apply the latest NLP technology to your own data with the use of Haystack's pipeline architecture. Implement production-ready semantic search, question answering, summarization and document ranking for a wide range of NLP applications. Evaluate components and fine-tune models. Ask questions in natural language and find granular answers in your documents using the latest QA models with the help of Haystack pipelines. Perform semantic search and retrieve ranked documents according to meaning, not just keywords! Make use of and compare the latest pre-trained transformer-based languages models like OpenAI’s GPT-3, BERT, RoBERTa, DPR, and more. Pick any Transformer model from Hugging Face's Model Hub, experiment, find the one that works. Use Haystack NLP components on top of Elasticsearch, OpenSearch, or plain SQL. Boost search performance with Pinecone, Milvus, FAISS, or Weaviate vector databases, and dense passage retrieval.
    Downloads: 5 This Week
    Last Update:
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  • 14
    Phidata

    Phidata

    Build multi-modal Agents with memory, knowledge, tools and reasoning

    Phidata is an open source platform for building, deploying, and monitoring AI agents. It enables users to create domain-specific agents with memory, knowledge, and external tools, enhancing AI capabilities for various tasks. The platform supports a range of large language models and integrates seamlessly with different databases, vector stores, and APIs. Phidata offers pre-configured templates to accelerate development and deployment, allowing users to quickly go from building agents to shipping them into production. It includes features like real-time monitoring, agent evaluations, and performance optimization tools, ensuring the reliability and scalability of AI solutions. Phidata also allows developers to bring their own cloud infrastructure, offering flexibility for custom setups. The platform provides robust support for enterprises, including security features, agent guardrails, and automated DevOps for smoother deployment processes.
    Downloads: 5 This Week
    Last Update:
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  • 15
    Agent S2

    Agent S2

    Agent S: an open agentic framework that uses computers like a human

    Simular's Agent S2 represents a leap forward in the development of computer-use agents, capable of autonomously interacting with a range of devices and interfaces. By integrating specialized AI models, Agent S2 delivers state-of-the-art performance, whether on desktop systems or smartphones. Through modular architecture, it efficiently handles complex tasks, such as navigating UIs, performing low-level actions like text selection, and executing high-level strategies like planning. Additionally, the system's proactive hierarchical planning allows for real-time adaptation, making it an ideal solution for businesses seeking to streamline operations and automate digital workflows. Agent S2 is designed with flexibility, enabling seamless scaling for future applications and tasks.
    Downloads: 4 This Week
    Last Update:
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  • 16
    Browser Use

    Browser Use

    Make websites accessible for AI agents

    Browser-Use is a framework that makes websites accessible for AI agents, enabling automated interactions and data extraction from web pages.
    Downloads: 4 This Week
    Last Update:
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  • 17
    Gemini Fullstack LangGraph Quickstart

    Gemini Fullstack LangGraph Quickstart

    Get started w/ building Fullstack Agents using Gemini 2.5 & LangGraph

    gemini-fullstack-langgraph-quickstart is a fullstack reference application from Google DeepMind’s Gemini team that demonstrates how to build a research-augmented conversational AI system using LangGraph and Google Gemini models. The project features a React (Vite) frontend and a LangGraph/FastAPI backend designed to work together seamlessly for real-time research and reasoning tasks. The backend agent dynamically generates search queries based on user input, retrieves information via the Google Search API, and performs reflective reasoning to identify knowledge gaps. It then iteratively refines its search until it produces a comprehensive, well-cited answer synthesized by the Gemini model. The repository provides both a browser-based chat interface and a command-line script (cli_research.py) for executing research queries directly. For production deployment, the backend integrates with Redis and PostgreSQL to manage persistent memory, streaming outputs, & background task coordination.
    Downloads: 4 This Week
    Last Update:
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  • 18
    Magentic UI

    Magentic UI

    A research prototype of a human-centered web agent

    Magentic-UI is a research prototype developed by Microsoft that serves as a human-centered interface powered by a multi-agent system. It enables users to automate complex web tasks, such as browsing, form filling, and data analysis, while maintaining control over the process. The system emphasizes transparency and user involvement, making it suitable for tasks requiring both automation and human oversight.
    Downloads: 4 This Week
    Last Update:
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  • 19
    MetaGPT

    MetaGPT

    The Multi-Agent Framework

    The Multi-Agent Framework: Given one line Requirement, return PRD, Design, Tasks, Repo. Assign different roles to GPTs to form a collaborative software entity for complex tasks. MetaGPT takes a one-line requirement as input and outputs user stories / competitive analysis/requirements/data structures / APIs / documents, etc. Internally, MetaGPT includes product managers/architects/project managers/engineers. It provides the entire process of a software company along with carefully orchestrated SOPs.
    Downloads: 4 This Week
    Last Update:
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  • 20
    gpt-engineer

    gpt-engineer

    Full stack AI software engineer

    gpt-engineer is an open-source platform designed to help developers automate the software development process using natural language. The platform allows users to specify software requirements in plain language, and the AI generates and executes the corresponding code. It can also handle improvements and iterative development, giving users more control over the software they’re building. Built with a terminal-based interface, gpt-engineer is customizable, enabling developers to experiment with AI-assisted programming and refine their development process. It is especially useful for automating the coding and iterative feedback loop in software development.
    Downloads: 4 This Week
    Last Update:
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  • 21
    npcpy

    npcpy

    The AI toolkit for the AI developer

    npcpy is a Python-based agent framework and command-line toolkit (the NPC Shell) for developers to build, test, and integrate AI agents into their workflows, including both command-line and GUI interfaces via NPC Studio. Welcome to npcpy, the core library of the NPC Toolkit that supercharges natural language processing pipelines and agent tooling. npcpy is a flexible framework for building state-of-the-art applications and conducting novel research with LLMs. The structure of npcpy also allows one to pass an npc to get_llm_response in addition to using the NPC's wrapped method, allowing you to be flexible in your implementation and testing.
    Downloads: 4 This Week
    Last Update:
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  • 22
    Agent Development Kit (ADK)

    Agent Development Kit (ADK)

    Open-source, code-first Python toolkit for building, evaluating, etc.

    ADK (Android Device Key) Python is a reference implementation by Google for working with Android attestation keys in Python. It facilitates the integration of Android attestation features into backends or systems that require verification of device identity and integrity. This is especially important in high-security applications where verifying that a device is genuine and uncompromised is critical. ADK Python helps developers verify hardware-backed keys, work with JSON Web Tokens (JWT), and integrate with Android’s Key Attestation infrastructure.
    Downloads: 3 This Week
    Last Update:
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  • 23
    Atomic Agents

    Atomic Agents

    Building AI agents, atomically

    The Atomic Agents framework is designed around the concept of atomicity to be an extremely lightweight and modular framework for building Agentic AI pipelines and applications without sacrificing developer experience and maintainability. The framework provides a set of tools and agents that can be combined to create powerful applications. It is built on top of Instructor and leverages the power of Pydantic for data and schema validation and serialization. All logic and control flows are written in Python, enabling developers to apply familiar best practices and workflows from traditional software development without compromising flexibility or clarity.
    Downloads: 3 This Week
    Last Update:
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  • 24
    CrewAI

    CrewAI

    Framework for orchestrating role-playing, autonomous AI agents

    Framework for orchestrating role-playing, autonomous AI agents. By fostering collaborative intelligence, CrewAI empowers agents to work together seamlessly, tackling complex tasks. The power of AI collaboration has too much to offer. CrewAI is designed to enable AI agents to assume roles, share goals, and operate in a cohesive unit - much like a well-oiled crew. Whether you're building a smart assistant platform, an automated customer service ensemble, or a multi-agent research team, CrewAI provides the backbone for sophisticated multi-agent interactions.
    Downloads: 3 This Week
    Last Update:
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  • 25
    GPTme

    GPTme

    Your agent in your terminal, equipped with local tools

    GPTMe is a personal AI chatbot designed for self-reflection, journaling, and productivity, using GPT models to generate personalized insights and responses.
    Downloads: 3 This Week
    Last Update:
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