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I don't know how many times I've searched the web for a win32 version of fuser. It is a great utility used in Unix/Linux for figuring out what process(es) have a file open (among other stuff).
Many would ask, "why not use handle.exe from SysInternals?"
While being a truly excellent utility (as all of SysInternals stuff is), it falls short -- at least for me -- for a couple of reasons:
1) It does filename pattern matching.
aps is like ps but with finer grained control over what processes are displayed. It can also kill (signal to) selected processes, or allow you to interactively kill selected processes. It has some of the functionality of pstree, killall and fuser.