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Comet MS/MS search engine

Comet open source tandem mass spectrometry (MS/MS) search engine.

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Comet is an open source tandem mass spectrometry (MS/MS) sequence database search engine. It identifies peptides by searching MS/MS spectra against sequences present in protein sequence databases.

Comet currently exists as a simple Windows or Linux command line binary that only does MS/MS database search. Supported input formats are mzXML, mzML, and ms2 files. Supported output formats are .out, SQT, and pepXML

Documentation and project website:

Comet MS/MS search engine Web Site

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Additional Project Details

Intended Audience


User Interface


Programming Language

C++, C


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