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Different from traditional peak callers that detect strong peaks only, ChIP-BIT2 detects both strong and weak peaks from enhancer regions, promoter regions or the whole genome using a pair of sample and input ChIP-seq experiments. It can automatically detect both narrow and wide peaks so can be applied to detecting transcription factor binding events or histone modifications without specific settings.
ChIP-BIT2 is an extended version of the ChIP-BIT method: a method designed mainly for detecting narrow peaks in promoter regions as described in the following paper:
Xi Chen et al., "ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles", Nucleic Acids Res (2016) 44 (7): e65.
Features
- ChIP-seq
- Weak Peak Detection
- Enhancer
- Promoter
- Transcription Factor
- Histone Modification
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