Menu

#1229 IPR019538 protein binding involved in protein folding?

InterPro
closed-fixed
nobody
None
5
2014-09-24
2014-09-09
No

IPR019538

I'm not sure about this. It seems to be a chaperone involved in "assembly" rather than folding?

Perhaps the description should be changedto reflect this (it doesn't appear to be a regulatory subunit as far as I can see, as it isn't part of the final complex?)

Discussion

  • Amaia Sangrador

    Amaia Sangrador - 2014-09-10
    • Group: UniProt --> InterPro
     
  • Amaia Sangrador

    Amaia Sangrador - 2014-09-10

    Yes, the 'protein binding involved in protein folding' is quite missleading, I have removed it and added the term for process 'proteasome assembly'. The name '26S Proteasome Non-ATPase Regulatory Subunit' is the one chosen by Uniprot, it is also called '26S Proteasome Subunit S5B'. It might have some indirect regulatory role in higher eukaryotes through TNF-a (PMID:22921402, Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-a/NFkB in Higher Eukaryotes)

     
  • rach_huntley

    rach_huntley - 2014-09-24
    • status: open --> closed-fixed
     

Log in to post a comment.