#1182 GEF should not be annotated to GO:0005096 - GTPase activator activity

[Valerie Wood]

A number of pombe gefs
SPAC24H6.09 gef1 RhoGEF Gef1 protein_coding I -1 472993 469981
SPAC31A2.16 gef2 RhoGEF Gef2 protein_coding I 1 419958 423991
SPBC29A3.17 gef3 RhoGEF Gef3 protein_coding II 1 2070147 2072679
SPAC16E8.09 scd1 RhoGEF Scd1 protein_coding I 1 3515632 3518734
SPBC4F6.10 vps901 guanyl-nucleotide exchange factor Vps901 (predicted) protein_coding II 1 2707735 2711825
SPBC29A10.11c vps902 guanyl-nucleotide exchange factor Vps902 (predicted)

(and most likely other organisms) are annotated to the term GO:0005096 - GTPase activator activity from UniProtKB-KW:KW-0343

BUT GEFSa are not
GO:0005096 - GTPase activator activity

see the annotation comment
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.

[Valerie Wood]

also applies to DP dissociation inhibitor
SPBC15C4.03 SPBC15C4.03 Rab geranylgeranyltransferase escort protein (predicted)
SPAC6F12.06 SPAC6F12.06 Rho GDP dissociation inhibitor Rdi1 (predicted)
gdi1 SPAC22H10.12c GDP dissociation inhibitor Gdi1 (predicted)

[Valerie Wood]

also Ran GTPase binding protein Sbp1

[rach_huntley]

Sent to UniProt.

[Marc Feuermann]

Hi Val,
As for the KW "cell cycle" I've also removed the KW-0343 from all these pombe entries. In this case, we need to clean much more entries from higher eukaryotes. This will need some more time and will be done progressively.
Thanks for the suggestion.
Regards
Marc.